Microbiome Regression-Based Kernel Association Tests
Description
Test for overall association between microbiome composition data
and phenotypes via phylogenetic kernels. The phenotype can be univariate
continuous or binary (Zhao et al. (2015) ),
survival outcomes (Plantinga et al. (2017) ),
multivariate (Zhan et al. (2017) ) and
structured phenotypes (Zhan et al. (2017) ).
The package can also use robust regression (unpublished work) and
integrated quantile regression (Wang et al. (2021) ).
In each case, the microbiome community effect is modeled nonparametrically
through a kernel function, which can incorporate phylogenetic tree information.