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MultiMeta (version 0.1)

betas_plot: Summary plot of the effect sizes and their correlations for a SNP of interest

Description

betas_plot returns a pdf file containing information about the meta-analysis combined effect sizes (beta coefficients) for a chosen SNP of interest.

Usage

betas_plot(SNP, res.file = NULL, data = NULL, trait.names = NULL, out.file = "Betas.pdf", col = NULL, orig.files = NULL, cohort.names = NULL)

Arguments

SNP
A SNP of interest, e.g. a SNP that is significantly associated to the analysed traits.
res.file
File name of the multi_meta results containing effect sizes for the above SNP. This is an alternative to data.
data
Object containing results from the multi_meta function and the above SNP. This is an alternative to file.
trait.names
Vector of analysed trait names to appear on the plot.
out.file
File name for the output plot.
col
Colours for the heat-map plot. Combinations of several colours are possible. If left blank a heat-map in scales of grey is produced.
orig.files
List of files with multivariate results for each cohort.
cohort.names
Names of the cohorts included in the meta-analysis.

Value

The output is a pdf file containing the described plot.

Details

The plot produced can be a useful tool for visualizing effect sizes across all traits, and the correlation between them. The plot will have two panels:
  1. effect sizes with 95% confidence interval for each trait;
  2. a heat-map showing correlations between betas.
Two different types of input are allowed:
  • a data.frame, containing the output from the multi_meta function for at least the specified SNP. This is the best choice if results have already been loaded into the R workspace.
  • a file name containing the output from multi_meta for at least the specified SNP. The separator field is set to white space. This file can be a subset of the complete results file (suggested), e.g. a file containing only significant SNPs.