NMdata

A fast R package for efficient data preparation, consistency-checking and post-processing in PK/PD modeling

Pharmacometrics and PK/PD modeling offers unique information for decision-making in several steps of drug development. However, it often takes a lot of work to get there, and there are many pitfalls along the way. NMdata helps simplifying this work and steering around the pitfalls or at least making sure we didn’t fall into them.

Flexibility first

Any functionality in the NMdata can be used independently of the rest of the package, and NMdata is not intended to force you to change any habits or preferences. Instead, NMdata tries to fit in with how you (or your colleague who worked on the project before you) do things. It likely provides helpful additions no matter what other tools you already use.

Automate book keeping and focus on modeling

Preparing data sets - and if you use NONMEM, reading the results data - can be tedious, and mistakes can lead to hours of frustration. NMdata provides useful tools (including automated checks) for these trivial tasks. Highlights in data set preparation and data checking:

• mergeCheck() Require left-join merging to only add columns - and nothing else. If rows get duplicated or disappear, throw an error.
• addTAPD() Automatically add time after previous dose, previous dose amount, cumulative number of doses and other related columns. Works with ADDL/II notation too.
• flagsAssign() and flagsCount() Automatically assign exclusion flags to data and tabulate number of subjects and observations excluded and/or retained due to each step.
• NMorderColumns Order columns in a Nonmem data set consistently and intuitively.
• NMwriteData() Feature-rich data writer for Nonmem data sets. Can return text to be used for $INPUT and $DATA sections.
• NMcheckData() Rigorous and extensive checking for structural errors and potential issues in Nonmem data sets.
• NMcheckColnames.R() Check data set against INPUT section of control streams.

Check out this vignette on data preparation.

Read model results in a consistent table structure

While NMdata does not organize all results into single objects that can be further processed, it offers efficient functions to read model results. These functions are all built to handle multiple models and return results in simple, consistent structures. Their results can easily be merged as needed. Notice, all of these functions basically just need a control stream path to run.

• NMscanData() Read and combine $TABLE output and input data. Feature-rich with support for the vast majority of models. Builds on NMscanInput() to automatically read input data and NMscanTables() to read all the output tables.
• NMreadExt() A feature-rich processor of ext files. Provides final parameter estimates with uncertainties and everything else provided in the ext file, iterations, objective function value and termination status
• NMreadParsText() Very flexible processor of comments in control stream parameter sections. As long as the comments provide consistent parameter information in almost any format, NMreadParsText() can turn it into a table.
• NMreadInits() Read and tabulate initial values, lower, upper limits, FIX and block structures based on parameter sections of control streams.
• NMrelate() Automatically connect parameters to variable names used in control stream code (say, CL=EXP(THETA(1)+ETA(1)) in control stream and NMrelate will “relate” THETA(1) and ETA(1) to CL. Powerful for QC and even simple parameter table generation.
• NMreadPhi() Reads individual posthoc estimates into a data.frame
• NMreadCov() Reads an estimated variance-covariance matrix and formats as a matrix
• NMreadShk() to read shrinkage tables

Vignettes:
Flexible Creation of Parameter Tables
NMscanData: Find And Combine All Output And Input Data

More information

The best place to browse information about the package is here. The quickest way in is the Cheatsheet. It does not cover any features related to generation of parameter tables, so you may also want to take a look at that vignette.

Also, check out the most recent vignette on Flexible Creation of Parameter Tables using NMdata.

How to install

NMdata is on CRAN and MPN. To install from the package archive you are already using, do:

install.packages("NMdata")
library(NMdata)

See further below for instructions on how to install from other sources than your default archive, if need be.

Prepare, check, and export PK/PD data

On the data-generation side, functionality is provided for documentation of the datasets while generating them. There are functions for automatic checks of (some) data merges, handling and counting of exclusions flags, final preparations for ensuring readability in NONMEM, and ensuring traceability of datasets back to data generation scripts.

Check data as read by NONMEM

The NMcheckData function will do an extensive and fully automated set of checks of the data before you run NONMEM. And did NONMEM not behave? NMcheckData can debug the data as seen by NONMEM. That’s right - it has never been easier to find data bugs.

Get the most recent version

If your archive has not been updated since July 2021, you may not find NMdata if you try to install with install.packages (option 1). In that case you have two other options. You can explicitly select CRAN for the installation. Or if you should want a version that has not yet reached CRAN, installing from Github is easy too.

## Option 1: Install from your default repository
install.packages("NMdata")

## Option 2: Install explicitly from CRAN
install.packages("NMdata",repos="https://cran.r-project.org")

## Option 3: Install from github
library(remotes)
install_github("nmautoverse/NMdata")

If you use the Github version, you may want to see the FAQ for how to install specific releases from Github (ensuring reproducibility).

Questions?

Check the FAQ, or ask on github

Issues?

The best way to report a bug or to request features is on github.

Code of Conduct

Please note that the patchwork project is released with a Contributor Code of Conduct. By contributing to this project, you agree to abide by its terms.