tblNCA: Table output NCA

Description

Do multiple NCA and returns a result table. See sNCA for more detail i.e. iAUC

Usage

tblNCA(concData, key = "Subject", colTime = "Time", colConc = "conc", dose = 0, 
       adm = "Extravascular", dur = 0, doseUnit = "mg", timeUnit = "h", 
       concUnit = "ug/L", down = "Linear", R2ADJ = 0, MW = 0, SS = FALSE, 
       iAUC = "", excludeDelta = 1)

Value

Basically same with sNCA

Arguments

concData: concentration data table
key: column names of concData to be shown in the output table
colTime: column name for time
colConc: column name for concentration
dose: administered dose
adm: one of "Bolus" or "Infusion" or "Extravascular" to indicate drug administration mode
dur: duration of infusion
doseUnit: unit of dose
timeUnit: unit of time
concUnit: unit of concentration
down: method to calculate AUC, "Linear" or "Log"
R2ADJ: Lowest threshold of adjusted R-square value to do manual slope determination
MW: molecular weight of drug
SS: if steady-state, this should be TRUE. AUCLST (AUClast) is used instead of AUCIFO (AUCinf) for the calculation of Vz (VZFO, VZO), CL (CLFO, CLO), and Vdss (VSSO).
iAUC: data.frame for interval AUC
excludeDelta: Improvement of R2ADJ larger than this value could exclude the last point. Default value 1 is for the compatibility with other software.

Author

Kyun-Seop Bae <k@acr.kr>

Details

Tabular output of NCA with many subjects. Author recommends to use excludeDelta option with about 0.3.

Examples

Run this code

tblNCA(Theoph, key="Subject", dose=320, concUnit="mg/L")
tblNCA(Indometh, key="Subject", colTime="time", colConc="conc", dose=25, 
       adm="Infusion", dur=0.5, concUnit="mg/L")

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