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NonCompart (version 0.8.4)

Noncompartmental Analysis for Pharmacokinetic Data

Description

Conduct a noncompartmental analysis with industrial strength. Some features are 1) Use of CDISC SDTM terms 2) Automatic or manual slope selection 3) Supporting both 'linear-up linear-down' and 'linear-up log-down' method 4) Interval(partial) AUCs with 'linear' or 'log' interpolation method 5) Steady-state analysis over the dosing interval (AUCTAU, CAVG, CL and Vz from AUCTAU) 6) Installation/Operational Qualification (IQ/OQ) reports in pdf. After installation, qualify the package in your own environment: run IQNCA() for Installation Qualification and OQNCA() for Operational Qualification. Run writeMD5NCA() once after installation so the IQ file-integrity check passes. To approve a report, sign it digitally in Adobe Acrobat Reader (generate with sigField=TRUE, or run addSigFieldNCA(), to add click-to-sign fields), instead of printing and scanning; or use signPDFNCA()/verifyPDFNCA() for a scriptable signature. * Reference: Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016. (ISBN:9198299107).

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Version

Install

install.packages('NonCompart')

Monthly Downloads

642

Version

0.8.4

License

GPL-3

Maintainer

Kyun-Seop Bae

Last Published

September 21st, 2026

Functions in NonCompart (0.8.4)

UnitUrine

Retuns a conversion factor for the amount calculation from urine concentration and volume
tblAUC

Table output of gAUCs
tblNCA

Table output NCA
writeMD5NCA

Write the MD5 integrity manifest for an installed package
IQNCA

Installation Qualification (IQ) report to a pdf file
NonCompart-package

Noncompartmental Analysis for Pharmacokinetic Data
Unit

Display CDISC standard units and multiplied factor of NCA results
DetSlope

Determine slope for the log(y) and x regression manually
AUC

Calculate Area Under the Curve (AUC) and Area Under the first Moment Curve (AUMC) in a table format
OQNCA

Operational Qualification (OQ) report to a pdf file
addSigFieldNCA

Add Acrobat-Reader signature fields to a report PDF
BestSlope

Choose the best-fit slope for the log(y) and x regression by the criteria of adjusted R-square.
sNCA

Simplest NCA
LogAUC

Area Under the Curve(AUC) and Area Under the first Moment Curve(AUMC) by linear-up log-down method
LinAUC

Area Under the Curve(AUC) and Area Under the first Moment Curve(AUMC) by linear trapezoidal method
Slope

Get the Slope of regression log(y) ~ x
IntAUC

Calculate interval AUC
Interpol

Interpolate y value
gIntAUC

Calculate interval AUC of general form
PQNCA

Performance Qualification (PQ) report to a pdf file
signPDFNCA

Digitally sign and verify a PDF report
gAUC

General Area Under the Curve
gInterpol

Interpolate y value for general y value not for concentration