ex_missing_drivers_b11

ex_missing_drivers_b12

An example where there are intermediate missing drivers. This is
fictitious and I've never seen it. But it is here to check plots work
even if there are no cases of some intermediate value of drivers (2 in
this case). b11 contains the full, original data, whereas b12 contains
the same data where there are no cases with exactly 2 drivers.

datasets

example-missing-drivers

Functions for forward population genetic simulation in
asexual populations, with special focus on cancer progression.
Fitness can be an arbitrary function of genetic interactions between
multiple genes or modules of genes, including epistasis, order
restrictions in mutation accumulation, and order effects.  Simulations
use continuous-time models and can include driver and passenger genes
and modules.  Also included are functions for simulating random DAGs
of the type found in Oncogenetic Tress, Conjunctive Bayesian Networks,
and other tumor progression models, and for plotting and sampling from
single or multiple realizations of the simulations, including
single-cell sampling, as well as functions for plotting the true
phylogenetic relationships of the clones.

Ramon Diaz-Uriarte

OncoSimulR

Forward Genetic Simulation of Cancer Progresion with Epistasis

example-missing-drivers function

Format

An example where there are intermediate missing drivers. This is
fictitious and I've never seen it. But it is here to check plots work
even if there are no cases of some intermediate value of drivers (2 in
this case). b11 contains the full, original data, whereas b12 contains
the same data where there are no cases with exactly 2 drivers.

example-missing-drivers: An example where there are intermediate missing drivers.

Description

Usage

Arguments

Format

See Also

Examples