OneArmPhaseTwoStudy (version 1.0.3)

get_p_KC: Calculates the p-value.

Description

Calculates the p-value for a Simon's two-stage design based on the work from Koyama and Chen.

Usage

get_p_KC(k, r1, n1, n, p0)

Arguments

k

overall observed responses.

r1

critical value for the first stage.

n1

sample size for the first stage.

n

overall sample size.

p0

response probability under the null hypothesis.

References

Koyama T and Chen H (2008): Proper inference from Simon's two-stage designs. Statistics in Medicine, 27(16):3145-3154.

Examples

# NOT RUN {
#Calculate a Simon's two-stage design
design <- getSolutions()$Solutions[3,] #minimax-design for the default values.

#Assume 9 responses were observed in the whole trial.
k = 9

p_val <- get_p_KC(k, design$r1, design$n1, design$n, design$p0)
# }