calc_Sigma

Helper function to calculate the covariance matrix from the group variances, cumulative allocation ratios
and gamma factors

Methods to calculate optimal design parameters
for one- and two-stage three-arm group-sequential gold-standard
non-inferiority trial designs
with or without binding or nonbinding futility boundaries,
as described in Meis et al. (2023) <doi:10.1002/sim.9630>.

Jan Meis

OptimalGoldstandardDesigns

Design Parameter Optimization for Gold-Standard Non-Inferiority
Trials

calc_Sigma function

<dl><dt>D</dt>
<dd>list containing all parameters of a the trial design.</dd></dl>

Arguments

Helper function to calculate the covariance matrix from the group variances, cumulative allocation ratios
and gamma factors — calc_Sigma

<dl>

<dt>D</dt>
<dd>list containing all parameters of a the trial design.</dd>

</dl>

calc_Sigma: Helper function to calculate the covariance matrix from the group variances, cumulative allocation ratios and gamma factors

Description

Usage

Arguments