calc_nT1_wrt_bTC2e

Helper function to calculate the required sample size (of the stage 1 treatment group)
to achieve the target power given the bTC2e

Methods to calculate optimal design parameters
for one- and two-stage three-arm group-sequential gold-standard
non-inferiority trial designs
with or without binding or nonbinding futility boundaries,
as described in Meis et al. (2023) <doi:10.1002/sim.9630>.

Jan Meis

OptimalGoldstandardDesigns

Design Parameter Optimization for Gold-Standard Non-Inferiority
Trials

calc_nT1_wrt_bTC2e function

<dl><dt>bTC2e</dt>
<dd>second stage critical value for the TC testing problem.</dd>
<dt>D</dt>
<dd>list containing all parameters of a the trial design.</dd></dl>

Arguments

Helper function to calculate the required sample size (of the stage 1 treatment group)
to achieve the target power given the bTC2e — calc_nT1_wrt_bTC2e

<dl>

<dt>bTC2e</dt>
<dd>second stage critical value for the TC testing problem.</dd>


<dt>D</dt>
<dd>list containing all parameters of a the trial design.</dd>

</dl>

calc_nT1_wrt_bTC2e: Helper function to calculate the required sample size (of the stage 1 treatment group) to achieve the target power given the bTC2e

Description

Usage

Arguments