objective_twostage

Objective function for two-stage gold-standard designs

Methods to calculate optimal design parameters
for one- and two-stage three-arm group-sequential gold-standard
non-inferiority trial designs
with or without binding or nonbinding futility boundaries,
as described in Meis et al. (2023) <doi:10.1002/sim.9630>.

Jan Meis

OptimalGoldstandardDesigns

Design Parameter Optimization for Gold-Standard Non-Inferiority
Trials

objective_twostage function

<dl><dt>D</dt>
<dd>list containing all parameters of a the trial design.</dd></dl>

Arguments

Objective function for two-stage gold-standard designs — objective_twostage

<dl>

<dt>D</dt>
<dd>list containing all parameters of a the trial design.</dd>

</dl>

objective_twostage: Objective function for two-stage gold-standard designs

Description

Usage

Arguments