animals2

The <code>animals2</code> data frame has 18 rows and 4 columns, with some censored observations.

datasets

Conduct simulation-based customized power calculation
for clustered time to event data in a mixed crossed/nested design,
where a number of cell lines and a number of mice within each cell line are considered to achieve a desired statistical power,
motivated by Eckel-Passow and colleagues (2021) <doi:10.1093/neuonc/noab137> and Li and colleagues (2025) <doi:10.51387/25-NEJSDS76>.
This package provides two commonly used models for powering a design, linear mixed effects and Cox frailty model. Both models account for
within-subject (cell line) correlation while holding different distributional assumptions about the outcome.
Alternatively, the counterparts of fixed effects model are also available, which produces similar estimates of statistical power.

Shanpeng Li

PDXpower

Time to Event Outcome in Experimental Designs of Pre-Clinical
Studies

Gang Li

animals2 function

This data frame contains the following columns:
<dl> <dt><code>ID</code></dt>
<dd>PDX line identifier.</dd>
 <dt><code>Y</code></dt>
<dd>time-to-event variable.</dd>
 <dt><code>Tx</code></dt>
<dd>treatment indicator. <code>0</code> denotes the placebo group and <code>1</code> the treatment group.</dd>
 <dt><code>status</code></dt>
<dd>event status. <code>0</code> denotes right-censoring and <code>1</code> the event occurs.</dd>
 
</dl>

Format

Simulated preliminary animals censored data — animals2

This data frame contains the following columns:
<dl>

 <dt><code>ID</code></dt>
<dd>PDX line identifier.</dd>


 <dt><code>Y</code></dt>
<dd>time-to-event variable.</dd>


 <dt><code>Tx</code></dt>
<dd>treatment indicator. <code>0</code> denotes the placebo group and <code>1</code> the treatment group.</dd>


 <dt><code>status</code></dt>
<dd>event status. <code>0</code> denotes right-censoring and <code>1</code> the event occurs.</dd>


 
</dl>

animals2: Simulated preliminary animals censored data

Description

Usage

Arguments

Format