plotpower

A function to generate a four-panel power curve under specified
number of PDX lines and number of individuals per PDX lines per treatment

Conduct simulation-based customized power calculation
for clustered time to event data in a mixed crossed/nested design,
where a number of cell lines and a number of mice within each cell line are considered to achieve a desired statistical power,
motivated by Eckel-Passow and colleagues (2021) <doi:10.1093/neuonc/noab137> and Li and colleagues (2025) <doi:10.51387/25-NEJSDS76>.
This package provides two commonly used models for powering a design, linear mixed effects and Cox frailty model. Both models account for
within-subject (cell line) correlation while holding different distributional assumptions about the outcome.
Alternatively, the counterparts of fixed effects model are also available, which produces similar estimates of statistical power.

Shanpeng Li

PDXpower

Time to Event Outcome in Experimental Designs of Pre-Clinical
Studies

Gang Li

plotpower function

<dl><dt>object</dt>
<dd>object of class 'PowerTable'.</dd>
<dt>ylim</dt>
<dd>limit of y axis.</dd>
<dt>x.axis.n.breaks</dt>
<dd>number of breaks of the x axis. Default is 10.</dd>
<dt>y.axis.n.breaks</dt>
<dd>number of breaks of the y axis. Default is 10.</dd>
<dt>cut.off</dt>
<dd>a number to indicate the cut-off for power analysis. Default is 0.8.</dd>
<dt>legend.position</dt>
<dd>the position of legends ("none", "left", "right", "bottom", "top", or two-element numeric vector).</dd></dl>

Arguments

A function to generate a four-panel power curve under specified
number of PDX lines and number of individuals per PDX lines per treatment — plotpower

<dl>

<dt>object</dt>
<dd>object of class 'PowerTable'.</dd>


<dt>ylim</dt>
<dd>limit of y axis.</dd>


<dt>x.axis.n.breaks</dt>
<dd>number of breaks of the x axis. Default is 10.</dd>


<dt>y.axis.n.breaks</dt>
<dd>number of breaks of the y axis. Default is 10.</dd>


<dt>cut.off</dt>
<dd>a number to indicate the cut-off for power analysis. Default is 0.8.</dd>


<dt>legend.position</dt>
<dd>the position of legends ("none", "left", "right", "bottom", "top", or two-element numeric vector).</dd>

</dl>

plotpower: A function to generate a four-panel power curve under specified number of PDX lines and number of individuals per PDX lines per treatment

Description

Usage

Value

Arguments