AdministrationConstraint-class

AdministrationConstraint

The class <code>AdministrationConstraint</code> represents the constraint of an input to the system.
The class stores information concerning the constraints for the dosage regimen :
response of the model, type of administration, amount of dose.

Evaluate or optimize designs for nonlinear mixed effects models using the Fisher Information matrix. Methods used in the package refer to
Mentré F, Mallet A, Baccar D (1997) <doi:10.1093/biomet/84.2.429>,
Retout S, Comets E, Samson A, Mentré F (2007) <doi:10.1002/sim.2910>,
Bazzoli C, Retout S, Mentré F (2009) <doi:10.1002/sim.3573>,
Le Nagard H, Chao L, Tenaillon O (2011) <doi:10.1186/1471-2148-11-326>,
Combes FP, Retout S, Frey N, Mentré F (2013) <doi:10.1007/s11095-013-1079-3> and
Seurat J, Tang Y, Mentré F, Nguyen TT (2021) <doi:10.1016/j.cmpb.2021.106126>.

Romain Leroux

PFIM

Population Fisher Information Matrix

France Mentré

Hervé Le Nagard

Jérémy Seurat

Tran Bach Nguyen

Caroline Bazzoli

Emmanuelle Comets

Anne Dubois

Cyrielle Dumont

Giulia Lestini

Thi Huyen Tram Nguyen

Thu Thuy Nguyen

Sylvie Retout

AdministrationConstraint-class function

Objects form the class <code>AdministrationConstraint</code> can be created by calls of the form #'<code>AdministrationConstraint(...)</code> where (...) are the parameters for the <code>AdministrationConstraint</code> objects.

Objects from the class

<dl>
<dt><code>response</code>:</dt>
<dd>A character giving the response of the model.</dd></dl><dt><code>Optimisability</code>:</dt>
<dd>A boolean giving if a dose is optimisable or not. If not the dose is fixed.</dd><dt><code>fixedDoses</code>:</dt>
<dd>A vector giving the fixed doses.</dd><dt><code>AllowedDoses</code>:</dt>
<dd>A vector giving the allowed amount of doses.</dd>

Slots for the <code>AdministrationConstraint</code> objects

Class "AdministrationConstraint" — AdministrationConstraint-class

Objects form the class <code>AdministrationConstraint</code> can be created by calls of the form #'<code>AdministrationConstraint(...)</code> where (...) are the parameters for the <code>AdministrationConstraint</code> objects.

<dl>
<dt><code>response</code>:</dt>
<dd>A character giving the response of the model.</dd>

<dt><code>Optimisability</code>:</dt>
<dd>A boolean giving if a dose is optimisable or not. If not the dose is fixed.</dd>

<dt><code>fixedDoses</code>:</dt>
<dd>A vector giving the fixed doses.</dd>

<dt><code>AllowedDoses</code>:</dt>
<dd>A vector giving the allowed amount of doses.</dd>


</dl>

AdministrationConstraint-class: Class "AdministrationConstraint"

Description

Arguments

Objects from the class

Slots for the <code>AdministrationConstraint</code> objects