Combinaison

Create all the possible combinaison for each Design and each Arms.

Evaluate or optimize designs for nonlinear mixed effects models using the Fisher Information matrix. Methods used in the package refer to
Mentré F, Mallet A, Baccar D (1997) <doi:10.1093/biomet/84.2.429>,
Retout S, Comets E, Samson A, Mentré F (2007) <doi:10.1002/sim.2910>,
Bazzoli C, Retout S, Mentré F (2009) <doi:10.1002/sim.3573>,
Le Nagard H, Chao L, Tenaillon O (2011) <doi:10.1186/1471-2148-11-326>,
Combes FP, Retout S, Frey N, Mentré F (2013) <doi:10.1007/s11095-013-1079-3> and
Seurat J, Tang Y, Mentré F, Nguyen TT (2021) <doi:10.1016/j.cmpb.2021.106126>.

Romain Leroux

PFIM

Population Fisher Information Matrix

France Mentré

Hervé Le Nagard

Jérémy Seurat

Tran Bach Nguyen

Caroline Bazzoli

Emmanuelle Comets

Anne Dubois

Cyrielle Dumont

Giulia Lestini

Thi Huyen Tram Nguyen

Thu Thuy Nguyen

Sylvie Retout

Combinaison function

<dl><dt>object</dt>
<dd>A <code>Optimization</code> object.</dd>
<dt>times</dt>
<dd>A <code>SAmplingTimes</code> object.</dd>
<dt>nTimesForEachVector</dt>
<dd>the number of sampling times for each vector of sampling times.</dd>
<dt>fixedTimes</dt>
<dd>the fixed sampling times.</dd>
<dt>n</dt>
<dd>parameter n</dd>
<dt>combin</dt>
<dd>parameter combin</dd></dl>

Arguments

Create all the possible combinaison for each Design and each Arms. — Combinaison

<dl>

<dt>object</dt>
<dd>A <code>Optimization</code> object.</dd>


<dt>times</dt>
<dd>A <code>SAmplingTimes</code> object.</dd>


<dt>nTimesForEachVector</dt>
<dd>the number of sampling times for each vector of sampling times.</dd>


<dt>fixedTimes</dt>
<dd>the fixed sampling times.</dd>


<dt>n</dt>
<dd>parameter n</dd>


<dt>combin</dt>
<dd>parameter combin</dd>

</dl>

Create all the possible combinaison for each Design and each Arms.

Combinaison: Create all the possible combinaison for each Design and each Arms.

Description

Usage

Value

Arguments