Combined2-class

Combined2

The class <code>{Combined2}</code> defines the the residual error variance according
to the formula g(sigma_inter, sigma_slope, c_error, f(x, theta)) = sigma_inter^2 + sigma_slope^2 * f_x_i_theta.

Evaluate or optimize designs for nonlinear mixed effects models using the Fisher Information matrix. Methods used in the package refer to
Mentré F, Mallet A, Baccar D (1997) <doi:10.1093/biomet/84.2.429>,
Retout S, Comets E, Samson A, Mentré F (2007) <doi:10.1002/sim.2910>,
Bazzoli C, Retout S, Mentré F (2009) <doi:10.1002/sim.3573>,
Le Nagard H, Chao L, Tenaillon O (2011) <doi:10.1186/1471-2148-11-326>,
Combes FP, Retout S, Frey N, Mentré F (2013) <doi:10.1007/s11095-013-1079-3> and
Seurat J, Tang Y, Mentré F, Nguyen TT (2021) <doi:10.1016/j.cmpb.2021.106126>.

Romain Leroux

PFIM

Population Fisher Information Matrix

France Mentré

Hervé Le Nagard

Jérémy Seurat

Tran Bach Nguyen

Caroline Bazzoli

Emmanuelle Comets

Anne Dubois

Cyrielle Dumont

Giulia Lestini

Thi Huyen Tram Nguyen

Thu Thuy Nguyen

Sylvie Retout

Combined2-class function

<code>{Combined2}</code> objects are typically created by calls to <code>{Combined2}</code>
and contain the following slots that are heritated from the class Combined2c:<dl>
<dt><code>.Object</code>:</dt>
<dd>An object of the class ModelError</dd><dt><code>sigma_inter</code>:</dt>
<dd>A numeric value giving the sigma inter of the error model.</dd><dt><code>sigma_slope</code>:</dt>
<dd>A numeric value giving the sigma slope of the error model.</dd>
</dl>

Objects from the class

Class "Combined2" — Combined2-class

<code>{Combined2}</code> objects are typically created by calls to <code>{Combined2}</code>
and contain the following slots that are heritated from the class Combined2c:<dl>
<dt><code>.Object</code>:</dt>
<dd>An object of the class ModelError</dd>

<dt><code>sigma_inter</code>:</dt>
<dd>A numeric value giving the sigma inter of the error model.</dd>

<dt><code>sigma_slope</code>:</dt>
<dd>A numeric value giving the sigma slope of the error model.</dd>


</dl>

Class "Combined2"

Combined2-class: Class "Combined2"

Description

Arguments

Objects from the class