DesignConstraint-class

DesignConstraint

The class <code>DesignConstraint</code>
defines information concerning the parametrization of the constraints on a design.

Evaluate or optimize designs for nonlinear mixed effects models using the Fisher Information matrix. Methods used in the package refer to
Mentré F, Mallet A, Baccar D (1997) <doi:10.1093/biomet/84.2.429>,
Retout S, Comets E, Samson A, Mentré F (2007) <doi:10.1002/sim.2910>,
Bazzoli C, Retout S, Mentré F (2009) <doi:10.1002/sim.3573>,
Le Nagard H, Chao L, Tenaillon O (2011) <doi:10.1186/1471-2148-11-326>,
Combes FP, Retout S, Frey N, Mentré F (2013) <doi:10.1007/s11095-013-1079-3> and
Seurat J, Tang Y, Mentré F, Nguyen TT (2021) <doi:10.1016/j.cmpb.2021.106126>.

Romain Leroux

PFIM

Population Fisher Information Matrix

France Mentré

Hervé Le Nagard

Jérémy Seurat

Tran Bach Nguyen

Caroline Bazzoli

Emmanuelle Comets

Anne Dubois

Cyrielle Dumont

Giulia Lestini

Thi Huyen Tram Nguyen

Thu Thuy Nguyen

Sylvie Retout

DesignConstraint-class function

Objects form the class DesignConstraint can be created by calls of the form <code>DesignConstraint(...)</code> where
(...) are the parameters for the <code>DesignConstraint</code> objects.

Objects from the class <code>DesignConstraint</code>

<dl>
<dt><code>name</code>:</dt>
<dd>A character string giving the name of the design - optional.</dd></dl><dt><code>PossibleArms</code>:</dt>
<dd>A list of arms for optimization.</dd><dt><code>totalNumberOfIndividuals</code>:</dt>
<dd>A numeric giving the total number of individuals in the design.</dd><dt><code>amountOfArm</code>:</dt>
<dd>A numeric giving the number of arms in the design.</dd><dt><code>samplingConstraints</code>:</dt>
<dd>A list giving the sampling constraints for the design.</dd><dt><code>administrationConstraints</code>:</dt>
<dd>A list giving the administration constraints for the design.</dd>

Slots for the <code>DesignConstraint</code> objects

Class "DesignConstraint" — DesignConstraint-class

Objects form the class DesignConstraint can be created by calls of the form <code>DesignConstraint(...)</code> where
(...) are the parameters for the <code>DesignConstraint</code> objects.

<dl>
<dt><code>name</code>:</dt>
<dd>A character string giving the name of the design - optional.</dd>

<dt><code>PossibleArms</code>:</dt>
<dd>A list of arms for optimization.</dd>

<dt><code>totalNumberOfIndividuals</code>:</dt>
<dd>A numeric giving the total number of individuals in the design.</dd>

<dt><code>amountOfArm</code>:</dt>
<dd>A numeric giving the number of arms in the design.</dd>

<dt><code>samplingConstraints</code>:</dt>
<dd>A list giving the sampling constraints for the design.</dd>

<dt><code>administrationConstraints</code>:</dt>
<dd>A list giving the administration constraints for the design.</dd>


</dl>

DesignConstraint-class: Class "DesignConstraint"

Description

Arguments

Objects from the class <code>DesignConstraint</code>

Slots for the <code>DesignConstraint</code> objects