EvaluateFIMsAndDesigns

Evaluate the FIMs and the Designs.

Evaluate or optimize designs for nonlinear mixed effects models using the Fisher Information matrix. Methods used in the package refer to
Mentré F, Mallet A, Baccar D (1997) <doi:10.1093/biomet/84.2.429>,
Retout S, Comets E, Samson A, Mentré F (2007) <doi:10.1002/sim.2910>,
Bazzoli C, Retout S, Mentré F (2009) <doi:10.1002/sim.3573>,
Le Nagard H, Chao L, Tenaillon O (2011) <doi:10.1186/1471-2148-11-326>,
Combes FP, Retout S, Frey N, Mentré F (2013) <doi:10.1007/s11095-013-1079-3> and
Seurat J, Tang Y, Mentré F, Nguyen TT (2021) <doi:10.1016/j.cmpb.2021.106126>.

Romain Leroux

PFIM

Population Fisher Information Matrix

France Mentré

Hervé Le Nagard

Jérémy Seurat

Tran Bach Nguyen

Caroline Bazzoli

Emmanuelle Comets

Anne Dubois

Cyrielle Dumont

Giulia Lestini

Thi Huyen Tram Nguyen

Thu Thuy Nguyen

Sylvie Retout

EvaluateFIMsAndDesigns function

<dl><dt>object</dt>
<dd>An <code>Optimization</code> object.</dd>
<dt>responseNumber</dt>
<dd>A numeric giving the number of responses.</dd>
<dt>responseNames</dt>
<dd>A character string giving the name of the response</dd>
<dt>doses</dt>
<dd>A vector of numeric values giving the doses.</dd>
<dt>times</dt>
<dd>A vector of numeric values giving the times doses.</dd>
<dt>admin</dt>
<dd>An <code>Administration</code> object giving the administration parameters.</dd>
<dt>samp</dt>
<dd>An <code>SamplingTimes</code> object giving the sampling times parameters.</dd>
<dt>statistical_model</dt>
<dd>A <code>statisticalModel</code> object.</dd>
<dt>cond_init</dt>
<dd>cond_init</dd>
<dt>totalNumberOfFIMs</dt>
<dd>A numeric giving the total number of FIMs.</dd>
<dt>typeFim</dt>
<dd>A character strgin gving the type of the FIM.</dd></dl>

Arguments

Evaluate the FIMs and the Designs. — EvaluateFIMsAndDesigns

<dl>

<dt>object</dt>
<dd>An <code>Optimization</code> object.</dd>


<dt>responseNumber</dt>
<dd>A numeric giving the number of responses.</dd>


<dt>responseNames</dt>
<dd>A character string giving the name of the response</dd>


<dt>doses</dt>
<dd>A vector of numeric values giving the doses.</dd>


<dt>times</dt>
<dd>A vector of numeric values giving the times doses.</dd>


<dt>admin</dt>
<dd>An <code>Administration</code> object giving the administration parameters.</dd>


<dt>samp</dt>
<dd>An <code>SamplingTimes</code> object giving the sampling times parameters.</dd>


<dt>statistical_model</dt>
<dd>A <code>statisticalModel</code> object.</dd>


<dt>cond_init</dt>
<dd>cond_init</dd>


<dt>totalNumberOfFIMs</dt>
<dd>A numeric giving the total number of FIMs.</dd>


<dt>typeFim</dt>
<dd>A character strgin gving the type of the FIM.</dd>

</dl>

Evaluate the FIMs and the Designs.

EvaluateFIMsAndDesigns: Evaluate the FIMs and the Designs.

Description

Usage

Value

Arguments