EvaluationModel

Evaluation for the model, analytic, ode, infusion

Evaluate or optimize designs for nonlinear mixed effects models using the Fisher Information matrix. Methods used in the package refer to
Mentré F, Mallet A, Baccar D (1997) <doi:10.1093/biomet/84.2.429>,
Retout S, Comets E, Samson A, Mentré F (2007) <doi:10.1002/sim.2910>,
Bazzoli C, Retout S, Mentré F (2009) <doi:10.1002/sim.3573>,
Le Nagard H, Chao L, Tenaillon O (2011) <doi:10.1186/1471-2148-11-326>,
Combes FP, Retout S, Frey N, Mentré F (2013) <doi:10.1007/s11095-013-1079-3> and
Seurat J, Tang Y, Mentré F, Nguyen TT (2021) <doi:10.1016/j.cmpb.2021.106126>.

Romain Leroux

PFIM

Population Fisher Information Matrix

France Mentré

Hervé Le Nagard

Jérémy Seurat

Tran Bach Nguyen

Caroline Bazzoli

Emmanuelle Comets

Anne Dubois

Cyrielle Dumont

Giulia Lestini

Thi Huyen Tram Nguyen

Thu Thuy Nguyen

Sylvie Retout

EvaluationModel function

<dl><dt>object</dt>
<dd>A <code>StatisticalModel</code> object.</dd>
<dt>samplingTimesModel</dt>
<dd>A vector containing the sampling times of the model.</dd>
<dt>cond_init_ode</dt>
<dd>A vector containing the initial conditions for an ODE model.</dd>
<dt>inputsModel</dt>
<dd>A list containing the parameters used for the model evaluation.</dd>
<dt>parametersGradient</dt>
<dd>A list containing the parameters used for the evaluation of the gradient of the model</dd>
<dt>computeFIM</dt>
<dd>A boolean giving TRUE id the FIM is compute, FALSE otherwise.</dd></dl>

Arguments

Evaluation for the model, analytic, ode, infusion — EvaluationModel

<dl>

<dt>object</dt>
<dd>A <code>StatisticalModel</code> object.</dd>


<dt>samplingTimesModel</dt>
<dd>A vector containing the sampling times of the model.</dd>


<dt>cond_init_ode</dt>
<dd>A vector containing the initial conditions for an ODE model.</dd>


<dt>inputsModel</dt>
<dd>A list containing the parameters used for the model evaluation.</dd>


<dt>parametersGradient</dt>
<dd>A list containing the parameters used for the evaluation of the gradient of the model</dd>


<dt>computeFIM</dt>
<dd>A boolean giving TRUE id the FIM is compute, FALSE otherwise.</dd>

</dl>

Evaluation for the model, analytic, ode, infusion

EvaluationModel: Evaluation for the model, analytic, ode, infusion

Description

Usage

Value

Arguments