PrepareFIMs

PrepareFIMs,FedorovWynnAlgorithm-method

PrepareFIMs,MultiplicativeAlgorithm-method

Prepare the FIMs for the optimization.
Prepare the Fisher Informations matrices.
Prepare the Fisher Informations Matrices.

Evaluate or optimize designs for nonlinear mixed effects models using the Fisher Information matrix. Methods used in the package refer to
Mentré F, Mallet A, Baccar D (1997) <doi:10.1093/biomet/84.2.429>,
Retout S, Comets E, Samson A, Mentré F (2007) <doi:10.1002/sim.2910>,
Bazzoli C, Retout S, Mentré F (2009) <doi:10.1002/sim.3573>,
Le Nagard H, Chao L, Tenaillon O (2011) <doi:10.1186/1471-2148-11-326>,
Combes FP, Retout S, Frey N, Mentré F (2013) <doi:10.1007/s11095-013-1079-3> and
Seurat J, Tang Y, Mentré F, Nguyen TT (2021) <doi:10.1016/j.cmpb.2021.106126>.

Romain Leroux

PFIM

Population Fisher Information Matrix

France Mentré

Hervé Le Nagard

Jérémy Seurat

Tran Bach Nguyen

Caroline Bazzoli

Emmanuelle Comets

Anne Dubois

Cyrielle Dumont

Giulia Lestini

Thi Huyen Tram Nguyen

Thu Thuy Nguyen

Sylvie Retout

PrepareFIMs function

<dl><dt>object</dt>
<dd>A <code>MultiplicativeAlgorithm</code> object.</dd>
<dt>statistical_model</dt>
<dd>A <code>StatisticalModel</code> object.</dd>
<dt>cond_init</dt>
<dd>: cond_init</dd>
<dt>constraint</dt>
<dd>: A <code>Constraint</code> object.</dd>
<dt>typeFim</dt>
<dd>: A character string giving the r=type of FIM : Population, Individual or Bayesian.</dd></dl>

Arguments

Prepare the FIMs for the optimization. — PrepareFIMs

<dl>

<dt>object</dt>
<dd>A <code>MultiplicativeAlgorithm</code> object.</dd>


<dt>statistical_model</dt>
<dd>A <code>StatisticalModel</code> object.</dd>


<dt>cond_init</dt>
<dd>: cond_init</dd>


<dt>constraint</dt>
<dd>: A <code>Constraint</code> object.</dd>


<dt>typeFim</dt>
<dd>: A character string giving the r=type of FIM : Population, Individual or Bayesian.</dd>

</dl>

Prepare the FIMs for the optimization.

PrepareFIMs: Prepare the FIMs for the optimization.

Description

Usage

Value

Arguments