SimplexAlgorithm-class

SimplexAlgorithm

The Class "SimplexAlgorithm" implements the Nelder-Mead method (also downhill simplex method, amoeba method) [1].

Evaluate or optimize designs for nonlinear mixed effects models using the Fisher Information matrix. Methods used in the package refer to
Mentré F, Mallet A, Baccar D (1997) <doi:10.1093/biomet/84.2.429>,
Retout S, Comets E, Samson A, Mentré F (2007) <doi:10.1002/sim.2910>,
Bazzoli C, Retout S, Mentré F (2009) <doi:10.1002/sim.3573>,
Le Nagard H, Chao L, Tenaillon O (2011) <doi:10.1186/1471-2148-11-326>,
Combes FP, Retout S, Frey N, Mentré F (2013) <doi:10.1007/s11095-013-1079-3> and
Seurat J, Tang Y, Mentré F, Nguyen TT (2021) <doi:10.1016/j.cmpb.2021.106126>.

Romain Leroux

PFIM

Population Fisher Information Matrix

France Mentré

Hervé Le Nagard

Jérémy Seurat

Tran Bach Nguyen

Caroline Bazzoli

Emmanuelle Comets

Anne Dubois

Cyrielle Dumont

Giulia Lestini

Thi Huyen Tram Nguyen

Thu Thuy Nguyen

Sylvie Retout

SimplexAlgorithm-class function

Objects form the class <code>SimplexAlgorithm</code> can be created by calls of the form <code>SimplexAlgorithm(...)</code> where
(...) are the parameters for the <code>SimplexAlgorithm</code> objects.

Objects from the class

<dl>
 <dt><code>pct_initial_simplex_building</code>:</dt>
<dd>A numeric giving the percentage of initial vertices for the simplex algorithm.</dd> <dt><code>max_iteration</code>:</dt>
<dd>A numeric giving the maximum of iterations.</dd> <dt><code>tolerance</code>:</dt>
<dd>A numeric giving the tolerance criteria for stopping the algorithm.</dd> <dt><code>showProcess</code>:</dt>
<dd>A boolean to show or not the process.</dd> <dt><code>OptimalDesign</code>:</dt>
<dd>A <code>Design</code> object giving the optimal design.</dd> 
</dl>

Slots for <code>SimplexAlgorithm</code> objects

Class "SimplexAlgorithm" — SimplexAlgorithm-class

Objects form the class <code>SimplexAlgorithm</code> can be created by calls of the form <code>SimplexAlgorithm(...)</code> where
(...) are the parameters for the <code>SimplexAlgorithm</code> objects.

<dl>
 <dt><code>pct_initial_simplex_building</code>:</dt>
<dd>A numeric giving the percentage of initial vertices for the simplex algorithm.</dd>

 <dt><code>max_iteration</code>:</dt>
<dd>A numeric giving the maximum of iterations.</dd>

 <dt><code>tolerance</code>:</dt>
<dd>A numeric giving the tolerance criteria for stopping the algorithm.</dd>

 <dt><code>showProcess</code>:</dt>
<dd>A boolean to show or not the process.</dd>

 <dt><code>OptimalDesign</code>:</dt>
<dd>A <code>Design</code> object giving the optimal design.</dd>

 
</dl>

SimplexAlgorithm-class: Class "SimplexAlgorithm"

Description

Arguments

Objects from the class

Slots for <code>SimplexAlgorithm</code> objects

References