fixedDoses

Set the value for the fixed doses in the administration constraints.

Evaluate or optimize designs for nonlinear mixed effects models using the Fisher Information matrix. Methods used in the package refer to
Mentré F, Mallet A, Baccar D (1997) <doi:10.1093/biomet/84.2.429>,
Retout S, Comets E, Samson A, Mentré F (2007) <doi:10.1002/sim.2910>,
Bazzoli C, Retout S, Mentré F (2009) <doi:10.1002/sim.3573>,
Le Nagard H, Chao L, Tenaillon O (2011) <doi:10.1186/1471-2148-11-326>,
Combes FP, Retout S, Frey N, Mentré F (2013) <doi:10.1007/s11095-013-1079-3> and
Seurat J, Tang Y, Mentré F, Nguyen TT (2021) <doi:10.1016/j.cmpb.2021.106126>.

Romain Leroux

PFIM

Population Fisher Information Matrix

France Mentré

Hervé Le Nagard

Jérémy Seurat

Tran Bach Nguyen

Caroline Bazzoli

Emmanuelle Comets

Anne Dubois

Cyrielle Dumont

Giulia Lestini

Thi Huyen Tram Nguyen

Thu Thuy Nguyen

Sylvie Retout

fixedDoses function

<dl><dt>object</dt>
<dd>An object <code>AdministrationConstraint</code> from the class AdministrationConstraint.</dd>
<dt>value</dt>
<dd>A numeric vector giving the value of the fixed dose.</dd></dl>

Arguments

Set the value for the fixed doses in the administration constraints. — fixedDoses

<dl>

<dt>object</dt>
<dd>An object <code>AdministrationConstraint</code> from the class AdministrationConstraint.</dd>


<dt>value</dt>
<dd>A numeric vector giving the value of the fixed dose.</dd>

</dl>

Set the value for the fixed doses in the administration constraints.

fixedDoses: Set the value for the fixed doses in the administration constraints.

Description

Usage

Value

Arguments