getDerivatesAdjustedByDistribution

Get the derivates adjusted by distribution of a <code>ModelParameter</code> object.

Evaluate or optimize designs for nonlinear mixed effects models using the Fisher Information matrix. Methods used in the package refer to
Mentré F, Mallet A, Baccar D (1997) <doi:10.1093/biomet/84.2.429>,
Retout S, Comets E, Samson A, Mentré F (2007) <doi:10.1002/sim.2910>,
Bazzoli C, Retout S, Mentré F (2009) <doi:10.1002/sim.3573>,
Le Nagard H, Chao L, Tenaillon O (2011) <doi:10.1186/1471-2148-11-326>,
Combes FP, Retout S, Frey N, Mentré F (2013) <doi:10.1007/s11095-013-1079-3> and
Seurat J, Tang Y, Mentré F, Nguyen TT (2021) <doi:10.1016/j.cmpb.2021.106126>.

Romain Leroux

PFIM

Population Fisher Information Matrix

France Mentré

Hervé Le Nagard

Jérémy Seurat

Tran Bach Nguyen

Caroline Bazzoli

Emmanuelle Comets

Anne Dubois

Cyrielle Dumont

Giulia Lestini

Thi Huyen Tram Nguyen

Thu Thuy Nguyen

Sylvie Retout

getDerivatesAdjustedByDistribution function

<dl><dt>object</dt>
<dd><code>ModelParameter</code> object.</dd>
<dt>df_total</dt>
<dd>df_total</dd></dl>

Arguments

Get the derivates adjusted by distribution of a ModelParameter object. — getDerivatesAdjustedByDistribution

<dl>

<dt>object</dt>
<dd><code>ModelParameter</code> object.</dd>


<dt>df_total</dt>
<dd>df_total</dd>

</dl>

Get the derivates adjusted by distribution of a <code>ModelParameter</code> object.

getDerivatesAdjustedByDistribution: Get the derivates adjusted by distribution of a `ModelParameter` object.

Description

Usage

Value

Arguments