Fim-class

A class storing information regarding the Fisher matrix.
Type of the Fisher information: population ("PopulationFIM"), individual ("IndividualFIM") or Bayesian ("BayesianFIM").

Evaluate or optimize designs for nonlinear mixed effects models using the Fisher Information matrix. Methods used in the package refer to
Mentré F, Mallet A, Baccar D (1997) <doi:10.1093/biomet/84.2.429>,
Retout S, Comets E, Samson A, Mentré F (2007) <doi:10.1002/sim.2910>,
Bazzoli C, Retout S, Mentré F (2009) <doi:10.1002/sim.3573>,
Le Nagard H, Chao L, Tenaillon O (2011) <doi:10.1186/1471-2148-11-326>,
Combes FP, Retout S, Frey N, Mentré F (2013) <doi:10.1007/s11095-013-1079-3> and
Seurat J, Tang Y, Mentré F, Nguyen TT (2021) <doi:10.1016/j.cmpb.2021.106126>.

Romain Leroux

PFIM

Population Fisher Information Matrix

France Mentré

Jérémy Seurat

Lucie Fayette

Emmanuelle Comets

Sylvie Retout

Fim-class function

Objects form the class <code>Fim</code> can be created by calls of the form <code>Fim(...)</code> where
(...) are the parameters for the <code>Fim</code> objects.

Objects from the class

<dl>
<dt><code>fisherMatrix</code>:</dt>
<dd>A matrix giving the Fisher matrix.</dd></dl><dt><code>fixedEffects</code>:</dt>
<dd>A matrix giving the fixed effects of the Fisher matrix.</dd><dt><code>varianceEffects</code>:</dt>
<dd>A matrix giving the variance effects of the Fisher matrix.</dd><dt><code>shrinkage</code>:</dt>
<dd>A vector giving the shrinkage value of the parameters.</dd>

Slots for <code>Fim</code> objects

Class "Fim" — Fim-class

Objects form the class <code>Fim</code> can be created by calls of the form <code>Fim(...)</code> where
(...) are the parameters for the <code>Fim</code> objects.

<dl>
<dt><code>fisherMatrix</code>:</dt>
<dd>A matrix giving the Fisher matrix.</dd>

<dt><code>fixedEffects</code>:</dt>
<dd>A matrix giving the fixed effects of the Fisher matrix.</dd>

<dt><code>varianceEffects</code>:</dt>
<dd>A matrix giving the variance effects of the Fisher matrix.</dd>

<dt><code>shrinkage</code>:</dt>
<dd>A vector giving the shrinkage value of the parameters.</dd>


</dl>

Fim-class: Class "Fim"

Description

Arguments

Objects from the class

Slots for <code>Fim</code> objects