Proportional-class

Proportional

The Class "Proportional" defines the the residual error variance according
to the formula g(sigma_inter, sigma_slope, c_error, f(x, theta)) = sigma_slope*f(x,theta).

Evaluate or optimize designs for nonlinear mixed effects models using the Fisher Information matrix. Methods used in the package refer to
Mentré F, Mallet A, Baccar D (1997) <doi:10.1093/biomet/84.2.429>,
Retout S, Comets E, Samson A, Mentré F (2007) <doi:10.1002/sim.2910>,
Bazzoli C, Retout S, Mentré F (2009) <doi:10.1002/sim.3573>,
Le Nagard H, Chao L, Tenaillon O (2011) <doi:10.1186/1471-2148-11-326>,
Combes FP, Retout S, Frey N, Mentré F (2013) <doi:10.1007/s11095-013-1079-3> and
Seurat J, Tang Y, Mentré F, Nguyen TT (2021) <doi:10.1016/j.cmpb.2021.106126>.

Romain Leroux

PFIM

Population Fisher Information Matrix

France Mentré

Jérémy Seurat

Lucie Fayette

Emmanuelle Comets

Sylvie Retout

Proportional-class function

Objects are typically created by calls to <code>Proportional</code> and contain the following slots
that are inherited from the class Combined1:

Objects from the Class Proportional

<dl>
<dt><code>.Object</code>:</dt>
<dd>An object of the Class <code>Proportional</code></dd></dl><dt><code>sigma_inter</code>:</dt>
<dd>A numeric value giving the sigma inter of the error model</dd><dt><code>sigma_slope</code>:</dt>
<dd>A numeric value giving the sigma slope of the error model</dd>

Slots for the <code>Proportional</code> objects

Class "Proportional" — Proportional-class

Objects are typically created by calls to <code>Proportional</code> and contain the following slots
that are inherited from the class Combined1:

<dl>
<dt><code>.Object</code>:</dt>
<dd>An object of the Class <code>Proportional</code></dd>

<dt><code>sigma_inter</code>:</dt>
<dd>A numeric value giving the sigma inter of the error model</dd>

<dt><code>sigma_slope</code>:</dt>
<dd>A numeric value giving the sigma slope of the error model</dd>


</dl>

Proportional-class: Class "Proportional"

Description

Arguments

Objects from the Class Proportional

Slots for the <code>Proportional</code> objects