getOutcomesGradient

Get the results of the evaluation of the outcome gradients.

Evaluate or optimize designs for nonlinear mixed effects models using the Fisher Information matrix. Methods used in the package refer to
Mentré F, Mallet A, Baccar D (1997) <doi:10.1093/biomet/84.2.429>,
Retout S, Comets E, Samson A, Mentré F (2007) <doi:10.1002/sim.2910>,
Bazzoli C, Retout S, Mentré F (2009) <doi:10.1002/sim.3573>,
Le Nagard H, Chao L, Tenaillon O (2011) <doi:10.1186/1471-2148-11-326>,
Combes FP, Retout S, Frey N, Mentré F (2013) <doi:10.1007/s11095-013-1079-3> and
Seurat J, Tang Y, Mentré F, Nguyen TT (2021) <doi:10.1016/j.cmpb.2021.106126>.

Romain Leroux

PFIM

Population Fisher Information Matrix

France Mentré

Jérémy Seurat

Lucie Fayette

Emmanuelle Comets

Sylvie Retout

getOutcomesGradient function

<dl><dt>object</dt>
<dd>An object <code>Design</code> from the class Design.</dd></dl>

Arguments

Get the results of the evaluation of the outcome gradients. — getOutcomesGradient

<dl>

<dt>object</dt>
<dd>An object <code>Design</code> from the class Design.</dd>

</dl>

getOutcomesGradient: Get the results of the evaluation of the outcome gradients.

Description

Usage

Value

Arguments