Arm-class

The class <code>Arm</code> combines the treatment and the sampling schedule.

Evaluate or optimize designs for nonlinear mixed effects models using the Fisher Information matrix. Methods used in the package refer to
Mentré F, Mallet A, Baccar D (1997) <doi:10.1093/biomet/84.2.429>,
Retout S, Comets E, Samson A, Mentré F (2007) <doi:10.1002/sim.2910>,
Bazzoli C, Retout S, Mentré F (2009) <doi:10.1002/sim.3573>,
Le Nagard H, Chao L, Tenaillon O (2011) <doi:10.1186/1471-2148-11-326>,
Combes FP, Retout S, Frey N, Mentré F (2013) <doi:10.1007/s11095-013-1079-3> and
Seurat J, Tang Y, Mentré F, Nguyen TT (2021) <doi:10.1016/j.cmpb.2021.106126>.

Romain Leroux

PFIM

Population Fisher Information Matrix

France Mentré

Jérémy Seurat

Lucie Fayette

Arm-class function

Objects form the class <code>Arm</code> can be created by calls of the form <code>Arm(...)</code> where (...) are the parameters for the <code>Arm</code> objects.

Objects from the class

<dl>
<dt><code>name</code>:</dt>
<dd>A string giving the name of the arm.</dd></dl><dt><code>size</code>:</dt>
<dd>An integer giving the number of subjects in the arm. By default set to 1.</dd><dt><code>administrations</code>:</dt>
<dd>A list of the administrations.</dd><dt><code>initialConditions</code>:</dt>
<dd>A list of the initial conditions.</dd><dt><code>samplingTimes</code>:</dt>
<dd>A list of the sampling times.</dd><dt><code>administrationsConstraints</code>:</dt>
<dd>A list of the administrations constraints.</dd><dt><code>samplingTimesConstraints</code>:</dt>
<dd>A list of the sampling times constraints.</dd>

Slots for the <code>Arm</code> objects

Class "Arm" — Arm-class

Objects form the class <code>Arm</code> can be created by calls of the form <code>Arm(...)</code> where (...) are the parameters for the <code>Arm</code> objects.

<dl>
<dt><code>name</code>:</dt>
<dd>A string giving the name of the arm.</dd>

<dt><code>size</code>:</dt>
<dd>An integer giving the number of subjects in the arm. By default set to 1.</dd>

<dt><code>administrations</code>:</dt>
<dd>A list of the administrations.</dd>

<dt><code>initialConditions</code>:</dt>
<dd>A list of the initial conditions.</dd>

<dt><code>samplingTimes</code>:</dt>
<dd>A list of the sampling times.</dd>

<dt><code>administrationsConstraints</code>:</dt>
<dd>A list of the administrations constraints.</dd>

<dt><code>samplingTimesConstraints</code>:</dt>
<dd>A list of the sampling times constraints.</dd>


</dl>

Arm-class: Class "Arm"

Description

Arguments

Objects from the class

Slots for the <code>Arm</code> objects