initialize,Combined1-method

Evaluate or optimize designs for nonlinear mixed effects models using the Fisher Information matrix. Methods used in the package refer to
Mentré F, Mallet A, Baccar D (1997) <doi:10.1093/biomet/84.2.429>,
Retout S, Comets E, Samson A, Mentré F (2007) <doi:10.1002/sim.2910>,
Bazzoli C, Retout S, Mentré F (2009) <doi:10.1002/sim.3573>,
Le Nagard H, Chao L, Tenaillon O (2011) <doi:10.1186/1471-2148-11-326>,
Combes FP, Retout S, Frey N, Mentré F (2013) <doi:10.1007/s11095-013-1079-3> and
Seurat J, Tang Y, Mentré F, Nguyen TT (2021) <doi:10.1016/j.cmpb.2021.106126>.

Romain Leroux

PFIM

Population Fisher Information Matrix

France Mentré

Jérémy Seurat

Lucie Fayette

initialize,Combined1-method function

<dl><dt>.Object</dt>
<dd>.Object</dd>
<dt>outcome</dt>
<dd>outcome</dd>
<dt>equation</dt>
<dd>equation</dd>
<dt>derivatives</dt>
<dd>derivatives</dd>
<dt>sigmaInter</dt>
<dd>sigmaInter</dd>
<dt>sigmaSlope</dt>
<dd>sigmaSlope</dd>
<dt>cError</dt>
<dd>cError</dd></dl>

Arguments

initialize — initialize,Combined1-method

<dl>

<dt>.Object</dt>
<dd>.Object</dd>


<dt>outcome</dt>
<dd>outcome</dd>


<dt>equation</dt>
<dd>equation</dd>


<dt>derivatives</dt>
<dd>derivatives</dd>


<dt>sigmaInter</dt>
<dd>sigmaInter</dd>


<dt>sigmaSlope</dt>
<dd>sigmaSlope</dd>


<dt>cError</dt>
<dd>cError</dd>

</dl>

initialize,Combined1-method: initialize

Description

Usage

Value

Arguments