definePKModel

definePKModel: define a PK model from library of model
definePKModel ModelAnalyticInfusion
definePKModel
definePKModel
definePKModel: define PK model ode bolus
definePKModel: define a PK model from library of model
definePKModel: define a PK model from library of model
definePKModel: define PK model ode bolus

Evaluate or optimize designs for nonlinear mixed effects models using the Fisher Information matrix. Methods used in the package refer to
Mentré F, Mallet A, Baccar D (1997) <doi:10.1093/biomet/84.2.429>,
Retout S, Comets E, Samson A, Mentré F (2007) <doi:10.1002/sim.2910>,
Bazzoli C, Retout S, Mentré F (2009) <doi:10.1002/sim.3573>,
Le Nagard H, Chao L, Tenaillon O (2011) <doi:10.1186/1471-2148-11-326>,
Combes FP, Retout S, Frey N, Mentré F (2013) <doi:10.1007/s11095-013-1079-3> and
Seurat J, Tang Y, Mentré F, Nguyen TT (2021) <doi:10.1016/j.cmpb.2021.106126>.

Romain Leroux

PFIM

Population Fisher Information Matrix

France Mentré

Jérémy Seurat

definePKModel function

<dl><dt>pkModel</dt>
<dd>An object of class <code>ModelODEInfusionDoseInEquation</code> that defines the PK model.</dd>
<dt>pfimproject</dt>
<dd>An object of class <code>PFIMProject</code> that defines the pfimproject.</dd></dl>

Arguments

definePKModel: define a PK model from library of model — definePKModel

<dl>

<dt>pkModel</dt>
<dd>An object of class <code>ModelODEInfusionDoseInEquation</code> that defines the PK model.</dd>


<dt>pfimproject</dt>
<dd>An object of class <code>PFIMProject</code> that defines the pfimproject.</dd>

</dl>

definePKModel: definePKModel: define a PK model from library of model

Description

Arguments