generateDosesCombination

generateDosesCombination: generate the combination for the doses.

Evaluate or optimize designs for nonlinear mixed effects models using the Fisher Information matrix. Methods used in the package refer to
Mentré F, Mallet A, Baccar D (1997) <doi:10.1093/biomet/84.2.429>,
Retout S, Comets E, Samson A, Mentré F (2007) <doi:10.1002/sim.2910>,
Bazzoli C, Retout S, Mentré F (2009) <doi:10.1002/sim.3573>,
Le Nagard H, Chao L, Tenaillon O (2011) <doi:10.1186/1471-2148-11-326>,
Combes FP, Retout S, Frey N, Mentré F (2013) <doi:10.1007/s11095-013-1079-3> and
Seurat J, Tang Y, Mentré F, Nguyen TT (2021) <doi:10.1016/j.cmpb.2021.106126>.

Romain Leroux

PFIM

Population Fisher Information Matrix

France Mentré

Jérémy Seurat

generateDosesCombination function

<dl><dt>design</dt>
<dd>An object <code>Design</code> giving the design.</dd></dl>

Arguments

generateDosesCombination: generate the combination for the doses. — generateDosesCombination

<dl>

<dt>design</dt>
<dd>An object <code>Design</code> giving the design.</dd>

</dl>

generateDosesCombination: generateDosesCombination: generate the combination for the doses.

Description

Value

Arguments