PKNCA (version 0.10.0)

choose_interp_extrap_method: Choose a method for calculation in the interval between concentrations

Description

This function should be used for any interpolation/extrapolation function. It will standardize the method of choosing which method to use for interpolation and extrapolation.

Usage

choose_interp_extrap_method(conc, time, interp_method, extrap_method, tmax)

Value

A character vector of extrapolation methods to use between each

conc and after the last conc. Values will be one or more of "linear" (use linear interpolation), "log" (use log interpolation), "zero" (the value is zero), and the last value may be "clastpred", "clastobs", or "zero" indicating extrapolation from tlast using lambda.z and clast,pred or clast,obs, or zero.

Arguments

conc

A vector of concentrations (NA values are not allowed)

time

A vector of times (NA values are not allowed)

interp_method

Method to use for interpolation between time points

extrap_method

Method to use for extrapolation after the last time point above (an AUC calculation method)

tmax

Time of maximum concentration

Examples

PKNCA:::choose_interp_extrap_method(
  conc=c(1, 2, 4, 2, 1, 0, 0),
  time=0:6,
  interp_method="lin up/log down",
  extrap_method="aucinf.obs"
)