PKNCA (version 0.10.0)

pk.calc.aucint: Calculate the AUC over an interval with interpolation and/or extrapolation of concentrations for the beginning and end of the interval.

Description

Calculate the AUC over an interval with interpolation and/or extrapolation of concentrations for the beginning and end of the interval.

Usage

pk.calc.aucint(
  conc,
  time,
  interval = NULL,
  start = NULL,
  end = NULL,
  clast = pk.calc.clast.obs(conc, time),
  lambda.z = NA,
  time.dose = NULL,
  route = "extravascular",
  duration.dose = 0,
  method = NULL,
  auc.type = "AUClast",
  conc.blq = NULL,
  conc.na = NULL,
  check = TRUE,
  ...,
  options = list()
)
pk.calc.aucint.last(
  conc,
  time,
  start = NULL,
  end = NULL,
  time.dose,
  ...,
  options = list()
)
pk.calc.aucint.all(
  conc,
  time,
  start = NULL,
  end = NULL,
  time.dose,
  ...,
  options = list()
)
pk.calc.aucint.inf.obs(
  conc,
  time,
  start = NULL,
  end = NULL,
  time.dose,
  lambda.z,
  clast.obs,
  ...,
  options = list()
)
pk.calc.aucint.inf.pred(
  conc,
  time,
  start = NULL,
  end = NULL,
  time.dose,
  lambda.z,
  clast.pred,
  ...,
  options = list()
)

Arguments

conc

Concentration measured

time

Time of concentration measurement (must be monotonically increasing and the same length as the concentration data)

interval

Numeric vector of two numbers for the start and end time of integration

start, end

The start and end of the interval (cannot be given if interval is given)

clast, clast.obs, clast.pred

The last concentration above the limit of quantification; this is used for AUCinf calculations. If provided as clast.obs (observed clast value, default), AUCinf is AUCinf,obs. If provided as clast.pred, AUCinf is AUCinf,pred.

lambda.z

The elimination rate (in units of inverse time) for extrapolation

time.dose, route, duration.dose

The time of doses, route of administration, and duration of dose used with interpolation and extrapolation of concentration data (see interp.extrap.conc.dose). If NULL, interp.extrap.conc will be used instead (assuming that no doses affecting concentrations are in the interval).

method

The method for integration (either 'lin up/log down' or 'linear')

auc.type

The type of AUC to compute. Choices are 'AUCinf', 'AUClast', and 'AUCall'.

conc.blq

How to handle BLQ values in between the first and last above LOQ concentrations. (See clean.conc.blq for usage instructions.)

conc.na

How to handle missing concentration values. (See clean.conc.na for usage instructions.)

check

Run check.conc.time, clean.conc.blq, and clean.conc.na?

...

Additional arguments passed to pk.calc.auxc and interp.extrap.conc

options

List of changes to the default PKNCA.options for calculations.

Functions

• pk.calc.aucint.last(): Interpolate or extrapolate concentrations for AUClast

• pk.calc.aucint.all(): Interpolate or extrapolate concentrations for AUCall

• pk.calc.aucint.inf.obs(): Interpolate or extrapolate concentrations for AUCinf.obs

• pk.calc.aucint.inf.pred(): Interpolate or extrapolate concentrations for AUCinf.pred

See Also

PKNCA.options, interp.extrap.conc.dose

Other AUC calculations: pk.calc.auxc()