pk.nca.interval: Compute all PK parameters for a single concentration-time data set

Description

For one subject/time range, compute all available PK parameters. All the internal options should be set by PKNCA.options prior to running. The only part that changes with a call to this function is the concentration and time.

Usage

pk.nca.interval(
  conc,
  time,
  volume,
  duration.conc,
  dose,
  time.dose,
  duration.dose,
  route,
  conc.group = NULL,
  time.group = NULL,
  volume.group = NULL,
  duration.conc.group = NULL,
  dose.group = NULL,
  time.dose.group = NULL,
  duration.dose.group = NULL,
  route.group = NULL,
  impute_method = NA_character_,
  include_half.life = NULL,
  exclude_half.life = NULL,
  subject,
  sparse,
  interval,
  options = list()
)

Value

A data frame with the start and end time along with all PK parameters for the interval

Arguments

conc, conc.group: Concentration measured for the current interval or all data for the group
time, time.group: Time of concentration measurement for the current interval or all data for the group
volume, volume.group: The volume (or mass) of the concentration measurement for the current interval or all data for the group (typically for urine and fecal measurements)
duration.conc, duration.conc.group: The duration of the concentration measurement for the current interval or all data for the group (typically for urine and fecal measurements)
dose, dose.group: Dose amount (may be a scalar or vector) for the current interval or all data for the group
time.dose, time.dose.group: Time of the dose for the current interval or all data for the group (must be the same length as dose or dose.group)
duration.dose, duration.dose.group: The duration of the dose administration for the current interval or all data for the group (typically zero for extravascular and intravascular bolus and nonzero for intravascular infusion)
route, route.group: The route of dosing for the current interval or all data for the group
impute_method: The method to use for imputation as a character string
include_half.life: An optional boolean vector of the concentration measurements to include in the half-life calculation. If given, no half-life point selection will occur.
exclude_half.life: An optional boolean vector of the concentration measurements to exclude from the half-life calculation.
subject: Subject identifiers (used for sparse calculations)
sparse: Should only sparse calculations be performed (TRUE) or only dense calculations (FALSE)?
interval: One row of an interval definition (see check.interval.specification for how to define the interval.
options: List of changes to the default PKNCA.options for calculations.

Description

Usage

Value

Arguments

See Also