Compute noncompartmental superposition for repeated dosing
superposition(conc, ...)# S3 method for PKNCAconc
superposition(conc, ...)
# S3 method for numeric
superposition(
conc,
time,
dose.input,
tau,
dose.times = 0,
dose.amount,
n.tau = Inf,
options = list(),
lambda.z,
clast.pred = FALSE,
tlast,
additional.times = numeric(),
check.blq = TRUE,
interp.method = NULL,
extrap.method = "AUCinf",
steady.state.tol = 0.001,
...
)
A data frame with columns named "conc" and "time".
Concentration measured
Additional arguments passed to the half.life
function if required to compute lambda.z.
Time of concentration measurement
The dose given to generate the conc and
time inputs. If missing, output doses will be assumed to be
equal to the input dose.
The dosing interval
The time of dosing within the dosing interval.
The min(dose.times) must be >= 0, and the
max(dose.times) must be < tau. There may be more
than one dose times given as a vector.
The doses given for the output. Linear
proportionality will be used from the input to output if they are
not equal. The length of dose.amount must be either 1 or matching
the length of dose.times.
The number of tau dosing intervals to simulate or
Inf for steady-state.
The PKNCA.options to use for the calculation (passed
on to subsequent functions like pk.calc.half.life).
The elimination rate (from the half life calculation, used to extrapolate beyond the maximum time observed).
To use predicted as opposed to observed Clast, either give the value for clast.pred here or set it to true (for automatic calculation from the half-life).
The time of last observed concentration above the limit of quantification. This is calculated if not provided.
Times to include in the final outputs in
addition to the standard times (see details). All
min(additional.times) must be >= 0, and the
max(additional.times) must be <= tau.
Must the first concentration measurement be below the limit of quantification?
See interp.extrap.conc
See interp.extrap.conc
The tolerance for assessing if steady-state has been achieved (between 0 and 1, exclusive).
The returned superposition times will include all of the
following times: 0 (zero), dose.times, time modulo tau
(shifting time for each dose time as well),
additional.times, and tau.
interp.extrap.conc