Create a PKNCAdose object
PKNCAdose(data, ...)# S3 method for default
PKNCAdose(data, ...)
# S3 method for tbl_df
PKNCAdose(data, ...)
# S3 method for data.frame
PKNCAdose(data, formula, route, rate, duration, time.nominal, exclude, ...)
A PKNCAconc object that can be used for automated NCA.
A data frame with time and the groups defined in formula.
Ignored.
The formula defining the dose.amount~time|groups where
time is the time of the dosing and dose.amount is the amount
administered at that time (see Details).
Define the route of administration. The value may be either a
column name from the data (checked first) or a character string of either
"extravascular" or "intravascular" (checked second). If given as a
column name, then every value of the column must be either
"extravascular" or "intravascular".
(optional) for "intravascular" dosing, the rate or
duration of dosing. If given as a character string, it is the name of a
column from the data, and if given as a number, it is the value for all
doses. Only one may be given, and if neither is given, then the dose is
assumed to be a bolus (duration=0). If rate is given, then the dose
amount must be given (the left hand side of the formula).
(optional) The name of the nominal time column (if the
main time variable is actual time. The time.nominal is not used during
calculations; it is available to assist with data summary and checking.
(optional) The name of a column with concentrations to exclude
from calculations and summarization. If given, the column should have
values of NA or "" for concentrations to include and non-empty text for
concentrations to exclude.
The formula for a PKNCAdose object can be
given three ways: one-sided (missing left side), one-sided (missing
right side), or two-sided. Each of the three ways can be given
with or without groups. When given one-sided missing the left
side, the left side can either be omitted or can be given as a
period (.): ~time|treatment+subject and
.~time|treatment+subject are identical, and dose-related NCA
parameters will all be reported as not calculable (for example,
clearance). When given one-sided missing the right side, the right
side must be specified as a period (.):
dose~.|treatment+subject, and only a single row may be given
per group. When the right side is missing, PKNCA assumes that the
same dose is given in every interval. When given as a two-sided
formula
Other PKNCA objects:
PKNCAconc(),
PKNCAdata(),
PKNCAresults()