interpolate.conc() and extrapolate.conc() returns an interpolated (or
extrapolated) concentration. interp.extrap.conc() will choose whether
interpolation or extrapolation is required and will also operate on many
concentrations. These will typically be used to estimate the concentration
between two measured concentrations or after the last measured concentration.
Of note, these functions will not extrapolate prior to the first point.
interp.extrap.conc(
conc,
time,
time.out,
lambda.z = NA,
clast = pk.calc.clast.obs(conc, time),
options = list(),
method = NULL,
auc.type = "AUCinf",
interp.method,
extrap.method,
...,
conc.blq = NULL,
conc.na = NULL,
check = TRUE
)interpolate.conc(
conc,
time,
time.out,
options = list(),
method = NULL,
interp.method,
conc.blq = NULL,
conc.na = NULL,
conc.origin = 0,
...,
check = TRUE
)
extrapolate.conc(
conc,
time,
time.out,
lambda.z = NA,
clast = pk.calc.clast.obs(conc, time),
auc.type = "AUCinf",
extrap.method,
options = list(),
conc.na = NULL,
conc.blq = NULL,
...,
check = TRUE
)
interp.extrap.conc.dose(
conc,
time,
time.dose,
route.dose = "extravascular",
duration.dose = NA,
time.out,
out.after = FALSE,
options = list(),
conc.blq = NULL,
conc.na = NULL,
...,
check = TRUE
)
The interpolated or extrapolated concentration value as a scalar
double (or vector for interp.extrap.conc()).
Measured concentrations
Time of the measurement of the concentrations
Time when interpolation is requested (vector for
interp.extrap.conc(), scalar otherwise)
The elimination rate (in units of inverse time) for extrapolation
The last observed concentration above the limit of
quantification. If not given, clast is calculated from
pk.calc.clast.obs()
List of changes to the default PKNCA options (see
PKNCA.options())
The method for integration (one of 'lin up/log down', 'lin-log', or 'linear')
The type of AUC to compute. Choices are 'AUCinf', 'AUClast', and 'AUCall'.
deprecated in favor of method and auc.type
Additional arguments passed to interpolate.conc() or
extrapolate.conc().
How to handle BLQ values. (See clean.conc.blq() for usage
instructions.)
How to handle NA concentrations. (See clean.conc.na())
Run assert_conc_time(), clean.conc.blq(), and
clean.conc.na()?
The concentration before the first measurement.
conc.origin is typically used to set predose values to zero (default),
set a predose concentration for endogenous compounds, or set predose
concentrations to NA if otherwise unknown.
Time of the dose
What is the route of administration ("intravascular" or "extravascular"). See the details for how this parameter is used.
What is the duration of administration? See the details for how this parameter is used.
Should interpolation occur from the data before (FALSE) or
after (TRUE) the interpolated point? See the details for how this
parameter is used. It only has a meaningful effect at the instant of an IV
bolus dose.
interpolate.conc(): Interpolate concentrations through Tlast (inclusive)
extrapolate.conc(): Extrapolate concentrations after Tlast
interp.extrap.conc.dose(): Interpolate and extrapolate concentrations
without interpolating or extrapolating beyond doses.
An NA value for the lambda.z parameter will prevent extrapolation.
Use lambda.z to extrapolate beyond the last point with the half-life.
If the last point is above the limit of quantification or missing, this is identical to 'AUCinf'. If the last point is below the limit of quantification, then linear interpolation between the Clast and the next BLQ is used for that interval and all additional points are extrapolated as 0.
Extrapolates all points after the last above the limit of quantification as 0.
duration.dose and direction.out are ignored if route.dose == "extravascular". direction.out is ignored if duration.dose > 0.
route.dose and duration.dose affect how interpolation/extrapolation of
the concentration occurs at the time of dosing. If route.dose == "intravascular" and duration.dose == 0 then extrapolation occurs for an IV
bolus using pk.calc.c0() with the data after dosing. Otherwise (either
route.dose == "extravascular" or duration.dose > 0), extrapolation occurs
using the concentrations before dosing and estimating the half-life (or more
precisely, estimating lambda.z). Finally, direction.out can change the
direction of interpolation in cases with route.dose == "intravascular" and
duration.dose == 0. When direction.out == "before" interpolation occurs
only with data before the dose (as is the case for route.dose == "extravascular"), but if direction.out == "after" interpolation occurs
from the data after dosing.
pk.calc.clast.obs(), pk.calc.half.life(), pk.calc.c0()