PKNCA (version 0.11.0)

superposition: Compute noncompartmental superposition for repeated dosing

Description

Compute noncompartmental superposition for repeated dosing

Usage

superposition(conc, ...)
# S3 method for PKNCAconc
superposition(conc, ...)
# S3 method for numeric
superposition(
  conc,
  time,
  dose.input = NULL,
  tau,
  dose.times = 0,
  dose.amount,
  n.tau = Inf,
  options = list(),
  lambda.z,
  clast.pred = FALSE,
  tlast,
  additional.times = numeric(),
  check.blq = TRUE,
  method = NULL,
  auc.type = "AUCinf",
  steady.state.tol = 0.001,
  ...
)

Value

A data frame with columns named "conc" and "time".

Arguments

conc

Measured concentrations

...

Additional arguments passed to the half.life function if required to compute lambda.z.

time

Time of the measurement of the concentrations

dose.input

The dose given to generate the conc and time inputs. If missing, output doses will be assumed to be equal to the input dose.

tau

The dosing interval

dose.times

The time of dosing within the dosing interval. The min(dose.times) must be >= 0, and the max(dose.times) must be < tau. There may be more than one dose times given as a vector.

dose.amount

The doses given for the output. Linear proportionality will be used from the input to output if they are not equal. The length of dose.amount must be either 1 or matching the length of dose.times.

n.tau

The number of tau dosing intervals to simulate or Inf for steady-state.

options

List of changes to the default PKNCA options (see PKNCA.options())

lambda.z

The elimination rate (in units of inverse time) for extrapolation

clast.pred

To use predicted as opposed to observed Clast, either give the value for clast.pred here or set it to true (for automatic calculation from the half-life).

tlast

The time of last observed concentration above the limit of quantification. This is calculated if not provided.

additional.times

Times to include in the final outputs in addition to the standard times (see details). All min(additional.times) must be >= 0, and the max(additional.times) must be <= tau.

check.blq

Must the first concentration measurement be below the limit of quantification?

method

The method for integration (one of 'lin up/log down', 'lin-log', or 'linear')

auc.type

The type of AUC to compute. Choices are 'AUCinf', 'AUClast', and 'AUCall'.

steady.state.tol

The tolerance for assessing if steady-state has been achieved (between 0 and 1, exclusive).

Details

The returned superposition times will include all of the following times: 0 (zero), dose.times, time modulo tau (shifting time for each dose time as well), additional.times, and tau.

See Also

interp.extrap.conc()