PKNCA (version 0.9.4)

PKNCA: Compute noncompartmental pharmacokinetics

Description

Compute pharmacokinetic (PK) noncompartmental analysis (NCA) parameters.

Details

PKNCA has been cross-validated with both Phoenix WinNonlin(R) and Pumas (click here for the cross-validation article)

A common workflow would load data from a file or database into a data.frame then run the following code.

Examples

# NOT RUN {
# Load concentration-time data into a data.frame called d.conc
# with columns named "conc", "time", and "subject".
my.conc <- PKNCAconc(d.conc, conc~time|subject)
# Load dose-time data into a data.frame called d.dose
# with columns named "dose", "time", and "subject".
my.dose <- PKNCAdose(d.dose, dose~time|subject)
# Combine the concentration-time and dose-time data into an object
# ready for calculations.
my.data <- PKNCAdata(my.conc, my.dose)
# Perform the calculations
my.results <- pk.nca(my.data)
# Look at summary results
summary(my.results)
# Look at a listing of results
as.data.frame(my.results)
# }