add_ruv

Add residual variability to the dependent variable

Simulate dose regimens for pharmacokinetic-pharmacodynamic (PK-PD)
models described by differential equation (DE) systems. Simulation using
ADVAN-style analytical equations is also supported (Abuhelwa et al. (2015)
<doi:10.1016/j.vascn.2015.03.004>).

Ron Keizer

PKPDsim

Tools for Performing Pharmacokinetic-Pharmacodynamic Simulations

Jasmine Hughes

Dominic Tong

Kara Woo

Jordan Brooks

InsightRX 

add_ruv function

<dl><dt>x</dt>
<dd>dependent value without residual variability</dd>
<dt>ruv</dt>
<dd>list specifying proportional, additive and/or exponential errors (<code>prop</code>, <code>add</code>, <code>exp</code>)</dd>
<dt>obs_type</dt>
<dd>vector of observation types</dd></dl>

Arguments

Add residual variability to the dependent variable — add_ruv

<dl>

<dt>x</dt>
<dd>dependent value without residual variability</dd>


<dt>ruv</dt>
<dd>list specifying proportional, additive and/or exponential errors (<code>prop</code>, <code>add</code>, <code>exp</code>)</dd>


<dt>obs_type</dt>
<dd>vector of observation types</dd>

</dl>

add_ruv: Add residual variability to the dependent variable

Description

Usage

Value

Arguments