PKPDsim (version 1.4.0)

calc_auc_analytic: Convenience function to calculate the AUC based on PK model parameters at any given moment, for linear iv models.

Description

Convenience function to calculate the AUC based on PK model parameters at any given moment, for linear iv models.

Usage

calc_auc_analytic(
  f = c("1cmt_iv_infusion", "2cmt_iv_infusion", "3cmt_iv_infusion", "1cmt_iv_bolus",
    "2cmt_iv_bolus", "3cmt_iv_bolus"),
  parameters,
  regimen = NULL,
  dose = NULL,
  interval = NULL,
  t_inf = NULL,
  t_obs = c(0, 24, 48, 72),
  ...
)

Value

a data.frame with t and auc

Arguments

f

analytic model to use, show available models using advan()

parameters

list of parameter estimates. Requires CL/V for 1-compartment models, CL/V/Q/V2 for 2-compartment models, and CL/V/Q/V2/Q2/V3 for 3-compartment models.

regimen

PKPDsim regimen created using new_regimen. Not required, regimen can also be specified using dose, interval, and t_inf.

dose

dosing amount for regimen (single value). Only used if no regimen supplied.

interval

dosing interval for regimen (single value). Only used if no . regimen supplied.

t_inf

infusion length for regimen (single value). Only used if no regimen supplied.

t_obs

vector of observation times for AUC

...

optional arguments passed to advanc_create_data()

Examples

dat <- calc_auc_analytic(
  f = "2cmt_iv_infusion",
  regimen = new_regimen(
    amt = 1000, n = 10, type = "infusion",
    t_inf = 1, interval = 24
  ),
  parameters = list(CL = 5, V = 50, Q = 8, V2 = 150)
)