Basically it performs a PK simulation using analytic equations instead of ODEs to steady state (n=45 days, increased if needed).
calc_ss_analytic(
f = "1cmt_oral",
dose,
interval,
t_inf = NULL,
model,
parameters,
covariates = NULL,
map = NULL,
n_days = 45,
n_transit_compartments = 0,
auc = FALSE
)State vector of a linear pharmacokinetic system at steady state
analytic equation to use, must be one of names(advan_funcs)
dose
interval
infusion time
PKPDsim model
parameters list
covariates list
list for remapping parameters, ex: list(CL = "CL", V = "V")
number of days at which to assume steady state. Default is 45.
number of transit compartments, will insert n compartments between the first (dose) compartment and the second (central) compartment.
add (empty) AUC compartment at end of state vector?
It can also be used for models with transit compartments, however, the assumption is made that at the end of the dosing interval the amount in the transit compartments is negligible (0).