PKPDsim (version 1.4.0)

calculate_parameters: Calculate model-specific variables using a dummy call to sim_ode()

Description

This is a convenience function for PKPDsim users, it is not used inside the sim_ode()`` function in any way. This function is useful for converting from an estimated parameter to actual parameter, e.g. when clearance is specified as CLi = CL * (WT/70) * (1/CR)it can be used to calculateCLi` without having to write that function a second time in R.

Usage

calculate_parameters(
  ode = NULL,
  parameters = NULL,
  covariates = NULL,
  include_parameters = TRUE,
  include_variables = TRUE,
  regimen = NULL,
  t_obs = NULL,
  ...
)

Value

List of model-specific variables

Arguments

ode

PKPDsim model object

parameters

parameter list

covariates

covariate list. Make sure to include covariates at the right time point, since only last observed covariate values are used.

include_parameters

boolean, include parameters?

include_variables

boolean, include variables?

regimen

optional, provide a regimen object for the computation of the effective parameters. This is only relevant for models for which parameters depend on the dose or administration type, which is rare.

t_obs

optional, provide timepoint(s) at which to computate effective parameters. This is only relevant for models with time-varying fixed-effects. If unspecified, will evaluate parameters at t=0.

...

arguments to pass on to simulation function