mvrnorm2

Besides standard multivariate normal sampling (mvrnorm), allows exponential
multivariate normal and quasi-random multivariate normal (using the randtoolbox)
all using the same interface.

Simulate dose regimens for pharmacokinetic-pharmacodynamic (PK-PD)
models described by differential equation (DE) systems. Simulation using
ADVAN-style analytical equations is also supported (Abuhelwa et al. (2015)
<doi:10.1016/j.vascn.2015.03.004>).

Ron Keizer

PKPDsim

Tools for Performing Pharmacokinetic-Pharmacodynamic Simulations

Jasmine Hughes

Dominic Tong

Kara Woo

Jordan Brooks

InsightRX 

mvrnorm2 function

<dl><dt>n</dt>
<dd>number of samples</dd>
<dt>mu</dt>
<dd>mean</dd>
<dt>Sigma</dt>
<dd>covariance matrix</dd>
<dt>exponential</dt>
<dd>exponential distribution (i.e. multiply mu by exponential of sampled numbers)</dd>
<dt>sequence</dt>
<dd>any sequence available in the randtoolbox, e.g. <code>halton</code>, or <code>sobol</code></dd>
<dt>...</dt>
<dd>parameters passed to mvrnorm or randtoolbox sequence generator</dd></dl>

Arguments

More powerful multivariate normal sampling function — mvrnorm2

<dl>

<dt>n</dt>
<dd>number of samples</dd>


<dt>mu</dt>
<dd>mean</dd>


<dt>Sigma</dt>
<dd>covariance matrix</dd>


<dt>exponential</dt>
<dd>exponential distribution (i.e. multiply mu by exponential of sampled numbers)</dd>


<dt>sequence</dt>
<dd>any sequence available in the randtoolbox, e.g. <code>halton</code>, or <code>sobol</code></dd>


<dt>...</dt>
<dd>parameters passed to mvrnorm or randtoolbox sequence generator</dd>

</dl>

mvrnorm2: More powerful multivariate normal sampling function

Description

Usage

Value

Arguments