PKPDsim (version 1.4.0)

new_regimen: Dose regimen for sim_ode

Description

Create a dosing regimen for use with sim_ode

Usage

new_regimen(
  amt = 100,
  interval = NULL,
  n = 3,
  times = NULL,
  type = NULL,
  t_inf = NULL,
  rate = NULL,
  t_lag = NULL,
  cmt = NULL,
  checks = TRUE,
  ss = FALSE,
  n_ss = NULL,
  first_dose_time = now_utc()
)

Value

a list containing calculated VPC information, and a ggplot2 object

Arguments

amt

dosing amount, either a single value (which will repeated for multiple doses), or a vector with doses for each administration

interval

dosing interval (requires n as argument)

n

number of doses (requires interval as argument)

times

vector describing dosing times. Overrides specified times using interval and n arguments

type

either "infusion", "bolus", "oral", "sc" (subcutaneous), or "im" (intramuscular).

t_inf

infusion time (if type==infusion)

rate

infusion rate (if type==infusion). NULL by default. If specified, overrides t_inf

t_lag

lag time (can be applied to any dose type, not only oral). Will just be added to times

cmt

vector of dosing compartments (optional, if NULL will dosing compartment defined in model will be used)

checks

input checks. Remove to increase speed (e.g. for population-level estimation or optimal design)

ss

steady state? boolean value whether to simulate out to steady state first (steady state will be based on specified amt and interval, times will be ignored).

n_ss

how many doses to simulate before assumed steady state. Default is 4 * 24 / interval.

first_dose_time

datetime stamp of first dose (of class POSIXct). Default is current date time.

See Also

sim_ode

Examples

r1 <- new_regimen(amt=50, interval=12, n=20) # dose 50mg, q12hrs for 10 days
r2 <- new_regimen(amt=50, times=c(0:19)*12)  # same, but using explicit times
r3 <- new_regimen(amt=c(rep(100,4), rep(50,16)), times=c(0:19)*12)  # first 4 doses higher dose