pkpdsim_to_nlmixr

Convert a model generated with PKPDsim to an object for nlmixr

Simulate dose regimens for pharmacokinetic-pharmacodynamic (PK-PD)
models described by differential equation (DE) systems. Simulation using
ADVAN-style analytical equations is also supported (Abuhelwa et al. (2015)
<doi:10.1016/j.vascn.2015.03.004>).

Ron Keizer

PKPDsim

Tools for Performing Pharmacokinetic-Pharmacodynamic Simulations

Jasmine Hughes

Dominic Tong

Kara Woo

Jordan Brooks

InsightRX 

pkpdsim_to_nlmixr function

<dl><dt>model</dt>
<dd>PKPDsim model</dd>
<dt>parameters</dt>
<dd>list of parameters</dd>
<dt>omega</dt>
<dd>vector describing the lower-diagonal of the between-subject variability matrix</dd>
<dt>res_var</dt>
<dd>residual variability. Expected a list with arguments <code>prop</code>, <code>add</code>, and/or <code>exp</code>. NULL by default.</dd>
<dt>fixed</dt>
<dd>vector of fixed (not estimated) parameter names</dd>
<dt>ini_code</dt>
<dd>manually specify the <code>ini</code> block for nlmixr</dd>
<dt>model_code</dt>
<dd>manually specify the <code>model</code> block for nlmixr</dd>
<dt>model_par_code</dt>
<dd>manually specify the parameters section inside the <code>model</code> block for nlmixr</dd>
<dt>verbose</dt>
<dd>verbose, <code>TRUE</code> or <code>FALSE</code></dd>
<dt>...</dt>
<dd>passed on</dd></dl>

Arguments

Convert a model generated with PKPDsim to an object for nlmixr — pkpdsim_to_nlmixr

<dl>

<dt>model</dt>
<dd>PKPDsim model</dd>


<dt>parameters</dt>
<dd>list of parameters</dd>


<dt>omega</dt>
<dd>vector describing the lower-diagonal of the between-subject variability matrix</dd>


<dt>res_var</dt>
<dd>residual variability. Expected a list with arguments <code>prop</code>, <code>add</code>, and/or <code>exp</code>. NULL by default.</dd>


<dt>fixed</dt>
<dd>vector of fixed (not estimated) parameter names</dd>


<dt>ini_code</dt>
<dd>manually specify the <code>ini</code> block for nlmixr</dd>


<dt>model_code</dt>
<dd>manually specify the <code>model</code> block for nlmixr</dd>


<dt>model_par_code</dt>
<dd>manually specify the parameters section inside the <code>model</code> block for nlmixr</dd>


<dt>verbose</dt>
<dd>verbose, <code>TRUE</code> or <code>FALSE</code></dd>


<dt>...</dt>
<dd>passed on</dd>

</dl>

pkpdsim_to_nlmixr: Convert a model generated with PKPDsim to an object for nlmixr

Description

Usage

Value

Arguments