sim_core

Only core function of the simulation function, always just returns observations.
Mostly useful for estimations / optimal design. Has no checks (for speed)!

Simulate dose regimens for pharmacokinetic-pharmacodynamic (PK-PD)
models described by differential equation (DE) systems. Simulation using
ADVAN-style analytical equations is also supported (Abuhelwa et al. (2015)
<doi:10.1016/j.vascn.2015.03.004>).

Ron Keizer

PKPDsim

Tools for Performing Pharmacokinetic-Pharmacodynamic Simulations

Jasmine Hughes

Dominic Tong

Kara Woo

Jordan Brooks

InsightRX 

sim_core function

<dl><dt>sim_object</dt>
<dd>list with design and simulation parameters</dd>
<dt>ode</dt>
<dd>ode</dd>
<dt>duplicate_t_obs</dt>
<dd>allow duplicate t_obs in output? E.g. for optimal design calculations when t_obs = c(0,1,2,2,3). Default is FALSE.</dd>
<dt>t_init</dt>
<dd>time of initialization of the ODE system. Usually 0.</dd></dl>

Arguments

Only core function of the simulation function, always just returns observations.
Mostly useful for estimations / optimal design. Has no checks (for speed)! — sim_core

<dl>

<dt>sim_object</dt>
<dd>list with design and simulation parameters</dd>


<dt>ode</dt>
<dd>ode</dd>


<dt>duplicate_t_obs</dt>
<dd>allow duplicate t_obs in output? E.g. for optimal design calculations when t_obs = c(0,1,2,2,3). Default is FALSE.</dd>


<dt>t_init</dt>
<dd>time of initialization of the ODE system. Usually 0.</dd>

</dl>

Only core function of the simulation function, always just returns observations.
Mostly useful for estimations / optimal design. Has no checks (for speed)!

sim_core: Only core function of the simulation function, always just returns observations. Mostly useful for estimations / optimal design. Has no checks (for speed)!

Description

Usage

Value

Arguments