POD v1.2.0

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by Markus Boenn View Source

Probability of Detection for Qualitative PCR Methods

This tool computes the probability of detection (POD) curve and the limit of detection (LOD), i.e. the number of copies of the target DNA sequence required to ensure a 95 % probability of detection (LOD95). Other quantiles of the LOD can be specified. This is a reimplementation of the mathematical-statistical modelling of the validation of qualitative polymerase chain reaction (PCR) methods within a single laboratory as provided by the commercial tool 'PROLab' <http://quodata.de/>. The modelling itself has been described by Uhlig et al. (2015) <doi:10.1007/s00769-015-1112-9>.

Readme

This is the R package 'POD'.

Vignettes

A tutorial is provided for the usage of the Excel macro.

Linux users

To get vignettes under Linux, enter options(browser="firefox"); browseVignettes("POD")

Windows users

To get vignettes under Windows, enter options(browser="C:/Program Files (x86)/Google/Chrome/Application/chrome.exe") browseVignettes("POD") To use other browsers, adapt the path accordingly.

Functions in POD

Name	Description
print.pod	Summary of POD objects
foreign	Support Other Platforms
testdata	Get Test Data
computePOD	Compute the Probability Of Detection (POD)
analyzeSingleLab	Analyze Single Lab Qualitative PCR Outcomes
plotPOD	Generate Plot to Analyze Single Lab PCR Outcomes
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Vignettes of POD

Name
bibliography.bib
howto.excel.Rmd
sheetInput.png
sheetSettings.png
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Details

Type	Package
Date	2020-06-30
License	GPL-3
Encoding	UTF-8
LazyData	true
VignetteBuilder	knitr
RoxygenNote	6.1.1
NeedsCompilation	no
Packaged	2020-06-30 08:35:01 UTC; boenn
Repository	CRAN
Date/Publication	2020-06-30 08:40:07 UTC

depends	R (>= 3.4.0)
Contributors	Markus Boenn