POD v1.2.0

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Probability of Detection for Qualitative PCR Methods

This tool computes the probability of detection (POD) curve and the limit of detection (LOD), i.e. the number of copies of the target DNA sequence required to ensure a 95 % probability of detection (LOD95). Other quantiles of the LOD can be specified. This is a reimplementation of the mathematical-statistical modelling of the validation of qualitative polymerase chain reaction (PCR) methods within a single laboratory as provided by the commercial tool 'PROLab' <http://quodata.de/>. The modelling itself has been described by Uhlig et al. (2015) <doi:10.1007/s00769-015-1112-9>.

Readme

This is the R package 'POD'.

Vignettes

A tutorial is provided for the usage of the Excel macro.

Linux users

To get vignettes under Linux, enter options(browser="firefox"); browseVignettes("POD")

Windows users

To get vignettes under Windows, enter options(browser="C:/Program Files (x86)/Google/Chrome/Application/chrome.exe") browseVignettes("POD") To use other browsers, adapt the path accordingly.

Functions in POD

Name Description
print.pod Summary of POD objects
foreign Support Other Platforms
testdata Get Test Data
computePOD Compute the Probability Of Detection (POD)
analyzeSingleLab Analyze Single Lab Qualitative PCR Outcomes
plotPOD Generate Plot to Analyze Single Lab PCR Outcomes
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Vignettes of POD

Name
bibliography.bib
howto.excel.Rmd
sheetInput.png
sheetSettings.png
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Details

Type Package
Date 2020-06-30
License GPL-3
Encoding UTF-8
LazyData true
VignetteBuilder knitr
RoxygenNote 6.1.1
NeedsCompilation no
Packaged 2020-06-30 08:35:01 UTC; boenn
Repository CRAN
Date/Publication 2020-06-30 08:40:07 UTC
depends R (>= 3.4.0)
Contributors Markus Boenn

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