A rare variant association test that utilizes protein tertiary structure to increase signal and to identify likely causal variants. Performs structure-guided collapsing, which leads to local tests that borrow information from neighboring variants on a protein and that provide association information on a variant-specific level.
Rachel Marceau West, Shannon T. Holloway
Maintainer: Shannon T. Holloway <sthollow@ncsu.edu>
| Package: | POINT |
| Type: | Package |
| Version: | 1.1 |
| Date: | 2019-03-02 |
| License: | GPL-2 |
| Depends: | methods, stats, rARPACK, Matrix |
| Imports: | CompQuadForm |
Marceau West R, Lu W, Rotroff DM, Kuenemann MA, Chang SM, et al. (2019) Identifying individual risk rare variants using protein structure guided local tests (POINT). PLOS Computational Biology 15(2): e1006722.