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PRSPGx (version 0.3.0)

Construct PGx PRS

Description

Construct pharmacogenomics (PGx) polygenic risk score (PRS) with PRS-PGx-Unadj (unadjusted), PRS-PGx-CT (clumping and thresholding), PRS-PGx-L, -GL, -SGL (penalized regression), PRS-PGx-Bayes (Bayesian regression). Package is based on ''Pharmacogenomics Polyenic Risk Score for Drug Response Prediction Using PRS-PGx Methods'' by Zhai, S., Zhang, H., Mehrotra, D.V., and Shen, J., 2021 (submitted).

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Version

Install

install.packages('PRSPGx')

Monthly Downloads

115

Version

0.3.0

License

GPL (>= 2)

Maintainer

Song Zhai

Last Published

July 20th, 2022

Functions in PRSPGx (0.3.0)

PRS_Dis_CT

Construct disease PRS unadjusted or using clumping and thresholding
PRS_PGx_Lasso

Construct PGx PRS using penalized regression
PRS_PGx_Bayes

Construct PGx PRS using Bayesian regression
PRS_Dis_LDpred2

Construct disease PRS using LDpred2
PRS_PGx_CT

Construct PGx PRS unadjusted or using clumping and thresholding
PRSPGx.example

Simulated example data