rmsth

A function to estimate the restricted mean survival time (RMST) and its variance from data

Variance

restricted mean survival time

Calculates various functions needed for design and monitoring survival trials
accounting for complex situations such as delayed treatment effect, treatment crossover, non-uniform accrual,
and different censoring distributions between groups. The event time distribution is assumed to be
piecewise exponential (PWE) distribution and the entry time is assumed to be piecewise uniform distribution.
As compared with Version 1.2.1, two more types of hybrid crossover are added.
A bug is corrected in the function "pwecx" that calculates the crossover-adjusted survival, distribution,
density, hazard and cumulative hazard functions.
Also, to generate the crossover-adjusted event time random variable,  a more efficient
algorithm is used and the output includes crossover indicators.

Xiaodong Luo

PWEALL

Design and Monitoring of Survival Trials Accounting for Complex
Situations

Xuezhou Mao

Xun Chen

Hui Quan

Sanofi 

rmsth function

<dl> <dt>y</dt>
<dd>observed times</dd> <dt>d</dt>
<dd>non-censoring indicators</dd> <dt>tcut</dt>
<dd>time point at which rmst is calculated</dd> <dt>eps</dt>
<dd>A small number representing the error tolerance when comparing the event times</dd></dl>

Arguments

Author

Estimate the restricted mean survival time (RMST) and its variance from data — rmsth

<dl>

 <dt>y</dt>
<dd>observed times</dd>

 <dt>d</dt>
<dd>non-censoring indicators</dd>

 <dt>tcut</dt>
<dd>time point at which rmst is calculated</dd>

 <dt>eps</dt>
<dd>A small number representing the error tolerance when comparing the event times</dd>

</dl>

rmsth: Estimate the restricted mean survival time (RMST) and its variance from data

Description

Usage

Value

Arguments

Author

Details

References

Examples