wlrcal

A utility function to calculate the weighted log-rank statistics and their varainces given the weights

weighted log-rank

Calculates various functions needed for design and monitoring survival trials
accounting for complex situations such as delayed treatment effect, treatment crossover, non-uniform accrual,
and different censoring distributions between groups. The event time distribution is assumed to be
piecewise exponential (PWE) distribution and the entry time is assumed to be piecewise uniform distribution.
As compared with Version 1.2.1, two more types of hybrid crossover are added.
A bug is corrected in the function "pwecx" that calculates the crossover-adjusted survival, distribution,
density, hazard and cumulative hazard functions.
Also, to generate the crossover-adjusted event time random variable,  a more efficient
algorithm is used and the output includes crossover indicators.

Xiaodong Luo

PWEALL

Design and Monitoring of Survival Trials Accounting for Complex
Situations

Xuezhou Mao

Xun Chen

Hui Quan

Sanofi 

wlrcal function

<dl> <dt>n</dt>
<dd>total number of subjects in the study</dd> <dt>te</dt>
<dd>(ascendingly) ordered unique event times from both groups</dd> <dt>tfix</dt>
<dd>time point where weighted log-rank is calcualted</dd> <dt>dd1</dt>
<dd>number of events from treatment group at each <code>te</code></dd> <dt>dd0</dt>
<dd>number of events from control group at each <code>te</code></dd> <dt>r1</dt>
<dd>number of at-risk subjects from treatment group at each <code>te</code></dd> <dt>r0</dt>
<dd>number of at-risk subjects from control group at each <code>te</code></dd> <dt>weights</dt>
<dd>user specified weights, each column is a set of weights at each <code>te</code></dd> <dt>eps</dt>
<dd>tolerence when comparing event times</dd></dl>

Arguments

Author

A utility function to calculate the weighted log-rank statistics and their varainces given the weights — wlrcal

<dl>

 <dt>n</dt>
<dd>total number of subjects in the study</dd>

 <dt>te</dt>
<dd>(ascendingly) ordered unique event times from both groups</dd>

 <dt>tfix</dt>
<dd>time point where weighted log-rank is calcualted</dd>

 <dt>dd1</dt>
<dd>number of events from treatment group at each <code>te</code></dd>

 <dt>dd0</dt>
<dd>number of events from control group at each <code>te</code></dd>

 <dt>r1</dt>
<dd>number of at-risk subjects from treatment group at each <code>te</code></dd>

 <dt>r0</dt>
<dd>number of at-risk subjects from control group at each <code>te</code></dd>

 <dt>weights</dt>
<dd>user specified weights, each column is a set of weights at each <code>te</code></dd>

 <dt>eps</dt>
<dd>tolerence when comparing event times</dd>

</dl>

wlrcal: A utility function to calculate the weighted log-rank statistics and their varainces given the weights

Description

Usage

Value

Arguments

Author

Details

Examples